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REMIX SIGNED

Regulation of mitochondrial expression

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

REMIX project word cloud

Explore the words cloud of the REMIX project. It provides you a very rough idea of what is the project "REMIX" about.

calls parkinson expression avenues eukaryotic governing diseases either cellular energy encoded mitochondria genomes demands treatment interventions genes progress skills linked gene produces mutations food neurodegenerative metabolic nuclear myriad mitochondrial alzheimer multidisciplinary nature molecular generation convert remix despite combine forces form diabetes strategic genome relies superficial regulate aging human network join organelles 8500 translation groups transcription training teams replication mtdna mechanisms oxidative found phosphorylation atp cell dysfunction therapeutic area scientific emerged elucidation majority disease machineries pathologies variety prevalence scientists basic asymp oxphos surprising usable regulation disorders poorly unexplored

Project "REMIX" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET ZU KOELN Organization address address: ALBERTUS MAGNUS PLATZ city: KOELN postcode: 50931 website: www.uni-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.remix-itn.eu
Total cost	3˙920˙630 €
EC max contribution	3˙920˙630 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET ZU KOELN UNIVERSITAET ZU KOELN Organization address address: ALBERTUS MAGNUS PLATZ city: KOELN postcode: 50931 website: www.uni-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	coordinator	643˙809.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	546˙575.00
3	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	546˙575.00
4	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	527˙318.00
5	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	527˙318.00
6	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	353˙056.00
7	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	265˙226.00
8	KHONDRION BV KHONDRION BV Organization address address: VAN HEEMSTRAWEG 49 E city: BEUNINGEN postcode: 6641 AA website: http://www.khondrion.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BEUNINGEN)	participant	255˙374.00
9	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	255˙374.00
10	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	0.00

Map

Project objective

Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. The mitochondrial oxidative phosphorylation (OXPHOS) system, which produces the majority of cellular energy in the form of ATP, is controlled by two distinct genomes: the nuclear and the mitochondrial genome (mtDNA). Mutations in mitochondrial genes encoded by either genome could cause diseases affecting OXPHOS system, called mitochondrial diseases, whose prevalence has been estimated to be ≈1:8500. Moreover, dysfunction of mitochondrial OXPHOS system has emerged as a key factor in a myriad of “common” diseases, including neurodegenerative and metabolic disorders like Parkinson’s and Alzheimer’s Disease, Type 2 Diabetes, and was linked to aging process. Despite all this, it is surprising that our understanding of the mechanisms governing the mitochondrial gene expression and its associated pathologies remain superficial and therapeutic interventions unexplored. The basic machineries for mtDNA replication, mtDNA transcription and mitochondrial translation are known, but the regulation of these processes in response to metabolic demands is poorly understood. The complex nature of mitochondrial gene expression that relies on two different genomes calls for a multidisciplinary approach where different teams of researchers join forces. Studies in this area are not only of basic scientific interest but may also provide new avenues towards treatment of mitochondrial dysfunction in a variety of human diseases. The key aim of the REMIX Network is combine the skills of European research groups to provide strategic training of the next generation of scientists through a programme that will progress in the elucidation of the molecular mechanisms and pathways that regulate mitochondrial gene expression.

Deliverables

List of deliverables.
Advertising of positions and Recruitment of ESR	Other	2020-02-20 11:08:47
Summer School	Other	2020-02-20 11:08:47
Creation of Internal and External Web site	Websites, patent fillings, videos etc.	2020-02-20 11:08:47
Recruitment of Project Manager	Other	2020-02-20 11:08:47

Take a look to the deliverables list in detail: detailed list of REMIX deliverables.

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The information about "REMIX" are provided by the European Opendata Portal: CORDIS opendata.