ULTRACHIRAL SIGNED
Ultrasensitive chiral detection by signal-reversing cavity polarimetry: applications to in-situ proteomics, single-molecule chirality, HPLC analysis, medical diagnostics, and atmospheric studies
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the ULTRACHIRAL project. It provides you a very rough idea of what is the project "ULTRACHIRAL" about.
Project "ULTRACHIRAL" data sheet
The following table provides information about the project.
| Coordinator |
IDRYMA TECHNOLOGIAS KAI EREVNAS
Organization address contact info |
| Coordinator Country | Greece [EL] |
| Project website | http://ultrachiral.iesl.forth.gr |
| Total cost | 3˙999˙250 € |
| EC max contribution | 3˙999˙250 € (100%) |
| Programme |
1. H2020-EU.1.2.1. (FET Open) |
| Code Call | H2020-FETOPEN-1-2016-2017 |
| Funding Scheme | RIA |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | IDRYMA TECHNOLOGIAS KAI EREVNAS | EL (IRAKLEIO) | coordinator | 722˙500.00 |
| 2 | THE UNIVERSITY OF EXETER | UK (EXETER) | participant | 572˙000.00 |
| 3 | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE | CH (LAUSANNE) | participant | 567˙500.00 |
| 4 | PANEPISTIMIO KRITIS | EL (RETHIMNO) | participant | 544˙750.00 |
| 5 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | participant | 535˙000.00 |
| 6 | JOHANNES GUTENBERG-UNIVERSITAT MAINZ | DE (MAINZ) | participant | 501˙250.00 |
| 7 | PHOTEK LIMITED | UK (EAST SUSSEX) | participant | 318˙750.00 |
| 8 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (MUENCHEN) | participant | 237˙500.00 |
Map
Project objective
Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion €, and growing. Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are typically very weak, preventing important biological and medical applications. Recently, the project-coordinating FORTH team has introduced a new form of Chiral-Cavity-based Polarimetry (CCP) for chiral sensing, which has three groundbreaking advantages compared to commercial instruments: (a) The chiroptical signals are enhanced by the number of cavity passes (typically ~1000); (b) otherwise limiting birefringent backgrounds are suppressed; (c) rapid signal reversals give absolute polarimetry measurements, not requiring sample removal for a null-sample measurement. Together, these advantages allow improvement in chiral detection sensitivity by 3-6 orders of magnitude (depending on instrument complexity and price). ULTRACHIRAL aims to revolutionize existing applications of chiral sensing, but also to instigate important new domains which require sensitivities beyond current limits, including: (1) measuring protein structure in-situ, in solution, at surfaces, and within cells and membranes, thus realizing the “holy-grail” of proteomics; (2) coupling to high performance liquid chromatography (HPLC) for chiral identification of the components of complex mixtures, creating new standards for the pharmaceutical and chemical analysis industries; (3) chiral analysis of human bodily fluids as a diagnostic tool in medicine; (4) measurement of single-molecule chirality, by adapting CCP to microresonators, which have already demonstrated single-molecule detection; and (5) real-time chiral monitoring of terpene emissions from individual trees and forests, as a probe of forest ecology.
Deliverables
| Year 1 progress report | Documents, reports | 2019-08-07 12:34:10 |
| Social networks integration | Websites, patent fillings, videos etc. | 2019-08-07 12:34:10 |
| Project website | Websites, patent fillings, videos etc. | 2019-08-07 12:34:10 |
| Data Management Plan | Open Research Data Pilot | 2019-08-07 12:34:10 |
| Kick-off meeting report | Documents, reports | 2019-08-07 12:34:10 |
Take a look to the deliverables list in detail: detailed list of ULTRACHIRAL deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
A. J. Geddes, L. V. Skripnikov, A. Borschevsky, J. C. Berengut, V. V. Flambaum, T. P. Rakitzis Enhanced nuclear-spin-dependent parity-violation effects using the HgH 199 molecule published pages: , ISSN: 2469-9926, DOI: 10.1103/physreva.98.022508 |
Physical Review A 98/2 | 2020-03-05 |
| 2019 |
Ershad Mohammadi, Ahad Tavakoli, Parisa Dehkhoda, Yasaman Jahani, Kosmas L. Tsakmakidis, Andreas Tittl, Hatice Altug Accessible Superchiral Near-Fields Driven by Tailored Electric and Magnetic Resonances in All-Dielectric Nanostructures published pages: 1939-1946, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b01767 |
ACS Photonics 6/8 | 2020-03-05 |
| 2019 |
Michele Gianella, Sioned A. Press, Katherine M. Manfred, Helen C. Norman, Meez Islam, Grant A. D. Ritchie Sensitive detection of HO 2 radicals produced in an atmospheric pressure plasma using Faraday rotation cavity ring-down spectroscopy published pages: 124202, ISSN: 0021-9606, DOI: 10.1063/1.5119191 |
The Journal of Chemical Physics 151/12 | 2020-03-05 |
| 2019 |
Sotiris Droulias, Lykourgos Bougas Surface Plasmon Platform for Angle-Resolved Chiral Sensing published pages: 1485-1492, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.9b00137 |
ACS Photonics 6/6 | 2020-03-05 |
| 2019 |
Filiz Yesilkoy, Eduardo R. Arvelo, Yasaman Jahani, Mingkai Liu, Andreas Tittl, Volkan Cevher, Yuri Kivshar, Hatice Altug Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces published pages: 390-396, ISSN: 1749-4885, DOI: 10.1038/s41566-019-0394-6 |
Nature Photonics 13/6 | 2020-03-05 |
| 2019 |
K. L. Tsakmakidis, O. Reshef, E. Almpanis, G. P. Zouros, E. Mohammadi, D. Saadat, F. Sohrabi, N. Fahimi-Kashani, D. Etezadi, R. W. Boyd, H. Altug Ultrabroadband 3D invisibility with fast-light cloaks published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12813-2 |
Nature Communications 10/1 | 2020-03-05 |
| 2019 |
Oleg Tretiak, Peter Blümler, Lykourgos Bougas Variable single-axis magnetic-field generator using permanent magnets published pages: 115312, ISSN: 2158-3226, DOI: 10.1063/1.5130896 |
AIP Advances 9/11 | 2020-03-05 |
| 2019 |
Sotiris Droulias, Ioannis Katsantonis, Maria Kafesaki, Costas M. Soukoulis, Eleftherios N. Economou Chiral Metamaterials with P T Symmetry and Beyond published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.122.213201 |
Physical Review Letters 122/21 | 2020-03-05 |
| 2019 |
Georgios E Katsoprinakis, T Peter Rakitzis Cavity-based chiral polarimetry: parity nonconserving optical rotation in Cs, Dy, and HgH published pages: 213501, ISSN: 0953-4075, DOI: 10.1088/1361-6455/ab410b |
Journal of Physics B: Atomic, Molecular and Optical Physics 52/21 | 2020-03-05 |
| 2019 |
Michael Staudt, Joseph Byron, Karim Piquemal, Jonathan Williams Compartment specific chiral pinene emissions identified in a Maritime pine forest published pages: 1158-1166, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.11.146 |
Science of The Total Environment 654 | 2020-03-05 |
| 2019 |
Sotiris Droulias, Ioannis Katsantonis, Maria Kafesaki, Costas M. Soukoulis, Eleftherios N. Economou Accessible phases via wave impedance engineering with PT -symmetric metamaterials published pages: , ISSN: 2469-9950, DOI: 10.1103/physrevb.100.205133 |
Physical Review B 100/20 | 2020-03-05 |
| 2018 |
Andreas Tittl, Aleksandrs Leitis, Mingkai Liu, Filiz Yesilkoy, Duk-Yong Choi, Dragomir N. Neshev, Yuri S. Kivshar, Hatice Altug Imaging-based molecular barcoding with pixelated dielectric metasurfaces published pages: 1105-1109, ISSN: 0036-8075, DOI: 10.1126/science.aas9768 |
Science 360/6393 | 2019-08-07 |
| 2018 |
Daniel Rodrigo, Andreas Tittl, Nadine Ait-Bouziad, Aurelian John-Herpin, Odeta Limaj, Christopher Kelly, Daehan Yoo, Nathan J. Wittenberg, Sang-Hyun Oh, Hilal A. Lashuel, Hatice Altug Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04594-x |
Nature Communications 9/1 | 2019-08-07 |
| 2018 |
Dordaneh Etezadi, John B. Warner, Hilal A. Lashuel, Hatice Altug Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas published pages: 1109-1117, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00115 |
ACS Sensors 3/6 | 2019-08-07 |
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