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PFIMDULA SIGNED

Post-translational modifications during floral initiation: molecular dissection of the UFO-dependent LFY activation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PFIMDULA project word cloud

Explore the words cloud of the PFIMDULA project. It provides you a very rough idea of what is the project "PFIMDULA" about.

employment spectrometry maturity transcription e3 poorly developmental proteins biochemistry translational industry modify genetics skills acquire professional ufo ubiquitination mechanism skp1 principles elusive planta organisms complementary basis model assayed multidisciplinary function earth understand ligase outstanding environment technologies notably flowering leafy re throughput cullin post builds residues arabidopsis box ptm crystallography dependent plant lfy activation enforce interaction grenoble modifications background facilities degradation regulatory emphasis special ubiquitin successful flower mass animal expertise functional sectors group fellow structural plants network combined gene inflorescences french interacting orchestrated architecture academia master governing food flowers human centers biology

Project "PFIMDULA" data sheet

The following table provides information about the project.

Coordinator	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.lpcv.fr/Flo_Re
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-06-08 to 2019-06-07

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	coordinator	185˙076.00

Map

Project objective

Flowering plants are the most successful plant group on Earth and provide the basis for most human and animal food. The development of flowers is dependent on a gene regulatory network orchestrated by LEAFY (LFY), the master transcription factor. In Arabidopsis as in other flowering plants, LFY activity is dependent upon its interaction with UFO, a member of the Skp1–Cullin–F-box E3 ubiquitin ligase complex. The goal of this project is to understand why LFY requires interacting with UFO to build flowers. For this, we will apply state-of-the-art technologies including mass-spectrometry, crystallography, biochemistry and plant developmental genetics to identify and characterize the function of Post-Translational Modifications (PTM) on LFY or LFY interacting proteins, with special emphasis on ubiquitination. After identifying key residues involved in the LFY-UFO interaction or targeted by PTM, their functional importance will be assayed in planta. This project should facilitate better understanding of the mechanism of LFY activation. LEAFY and the development of flower will be used here as a model to understand the “activation by degradation” mechanism, still elusive in most organisms and poorly studied in plants. Moreover, understanding the principles governing LFY activation should provide means to modify at will the architecture of plant inflorescences. This project builds on the current background of the applicant in the field of Mass-Spectrometry combined with the outstanding expertise at Grenoble and high-throughput facilities in Structural biology and plant developmental genetics. Notably, the applicant will work within one of the top French Research Centers and in a multidisciplinary environment that will allow the fellow to acquire complementary ‘new knowledge and skills’ in structural biology and developmental genetics. This will re-enforce the fellow’s background and professional maturity for employment opportunities in both academia and industry sectors.

Publications

List of publications.
year	authors and title	journal	last update
2018	Claudius Marondedze, Xinyun Liu, Shihui Huang, Cynthia Wong, Xuan Zhou, Xutong Pan, Huiting An, Nuo Xu, Xuechen Tian, Aloysius Wong Towards a tailored indoor horticulture: a functional genomics guided phenotypic approach published pages: , ISSN: 2052-7276, DOI: 10.1038/s41438-018-0065-7	Horticulture Research 5/1	2019-08-05

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