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altEJrepair SIGNED

Characterisation of DNA Double-Strand Break Repair by Alternative End-Joining: Potential Targets for Cancer Therapy

Total Cost €

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EC-Contrib. €

0

Partnership

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 altEJrepair project word cloud

Explore the words cloud of the altEJrepair project. It provides you a very rough idea of what is the project "altEJrepair" about.

characterise    critical    hrd    signature    inhibitors    lesions    convinced    mutational    resolves    paving    senses    last    function    small    polymerase    utilisation    elusive    intricate    recognition    interconnections    shown    elucidate    treatments    abovementioned    basic    crosstalk    ej    action    molecule    light    remission    effectiveness    molecular    viability    identification    additionally    poorly    players    characterised    integral    limited    synthetic    minimise    tumour    interplay    lethality    humans    alt    theta    chemotherapeutics    mediated    deficient    shedding    anticancer    progression    despite    tumours    history    multidisciplinary    contributes    cell    pathogenic    changing    mechanisms    regulated    drug    dna    clinical    genetic    preventing    contribution    gaining    homologous    pol    few    hr    relevance    treatment    absence    elucidating    alternative    network    composition    damage    therapeutics    joining    regulation    recombination    implications    survival    cancer    patients    repair   

Project "altEJrepair" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 1˙498˙750.00

Map

 Project objective

DNA repair pathways evolved as an intricate network that senses DNA damage and resolves it in order to minimise genetic lesions and thus preventing tumour formation. Gaining in recognition the last few years, the alternative end-joining (alt-EJ) DNA repair pathway was recently shown to be up-regulated and required for cancer cell viability in the absence of homologous recombination-mediated repair (HR). Despite this integral role, the alt-EJ repair pathway remains poorly characterised in humans. As such, its molecular composition, regulation and crosstalk with HR and other repair pathways remain elusive. Additionally, the contribution of the alt-EJ pathway to tumour progression as well as the identification of a mutational signature associated with the use of alt-EJ has not yet been investigated. Moreover, the clinical relevance of developing small-molecule inhibitors targeting players in the alt-EJ pathway, such as the polymerase Pol Theta (Polθ), is of importance as current anticancer drug treatments have shown limited effectiveness in achieving cancer remission in patients with HR-deficient (HRD) tumours.

Here, we propose a novel, multidisciplinary approach that aims to characterise the players and mechanisms of action involved in the utilisation of alt-EJ in cancer. This understanding will better elucidate the changing interplay between different DNA repair pathways, thus shedding light on whether and how the use of alt-EJ contributes to the pathogenic history and survival of HRD tumours, eventually paving the way for the development of novel anticancer therapeutics.

For all the abovementioned reasons, we are convinced this project will have important implications in: 1) elucidating critical interconnections between DNA repair pathways, 2) improving the basic understanding of the composition, regulation and function of the alt-EJ pathway, and 3) facilitating the development of new synthetic lethality-based chemotherapeutics for the treatment of HRD tumours.

 Publications

year authors and title journal last update
List of publications.
2016 Zeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O’Leary, David Kozono, Alan D. D’Andrea, Raphael Ceccaldi
FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair
published pages: 2488-2499, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.05.031
Cell Reports 15/11 2020-03-25

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The information about "ALTEJREPAIR" are provided by the European Opendata Portal: CORDIS opendata.

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