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EQIPD SIGNED

European Quality In Preclinical Data

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EQIPD project word cloud

Explore the words cloud of the EQIPD project. It provides you a very rough idea of what is the project "EQIPD" about.

decisions report clinical science rigor gain recommendations treatments predictability solutions systematic pharmaceutical compliance joint criteria turn variables preclinical online academia sustainable impacting patients ring cross expansion data publications certified innovation quality emerge components strength psychosis alzheimer review exchange time robustness drivers validate framework outcomes meta disease pilot policy members education community principles sustainability cultural safety platform historical informed basic educational contributions decision validity core delphi applicability succeed consensus industry pivotal rigour form action experiments site freedom scheme eqipd market feasibility attest neuro regulated prospective outcome relevance influence pool governance effect made infrastructure training ripple patent enrolled scientific models junior neuroscience

Project "EQIPD" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.eqipd.org
Total cost	9˙845˙483 €
EC max contribution	4˙495˙523 € (46%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2016-09-two-stage
Funding Scheme	IMI2-RIA
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	coordinator	849˙133.00
2	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	456˙524.00
3	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX website: http://www.abdn.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABERDEEN)	participant	409˙110.00
4	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	371˙072.00
5	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	368˙299.00
6	PAASP GMBH PAASP GMBH Organization address address: AM AUKOPF 14-1 city: HEIDELBERG postcode: 69118 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	362˙337.00
7	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	301˙800.00
8	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	292˙502.00
9	Concentris Research Management GmbH Concentris Research Management GmbH Organization address address: Ludwigstr. 4 city: Fürstenfeldbruck postcode: D-82256 website: www.concentris.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Fürstenfeldbruck)	participant	232˙787.00
10	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	200˙414.00
11	PORSOLT SAS PORSOLT SAS Organization address address: ZA DE GLATIGNE city: LE GENEST SAINT-ISLE postcode: 53940 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LE GENEST SAINT-ISLE)	participant	115˙628.00
12	SYNAPTOLOGICS BV SYNAPTOLOGICS BV Organization address address: ACHILLESSTRAAT 28 2 city: AMSTERDAM postcode: 1008 BA website: www.synaptologics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	110˙628.00
13	STICHTING BURO ECNP STICHTING BURO ECNP Organization address address: BOLOGNALAAN 28 city: UTRECHT postcode: 3584 CJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	98˙305.00
14	NOLDUS INFORMATION TECHNOLOGY BV NOLDUS INFORMATION TECHNOLOGY BV Organization address address: NIEUWE KANAAL 5 city: WAGENINGEN postcode: 6709 PA website: www.noldus.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	89˙152.00
15	PHARMALEX BELGIUM PHARMALEX BELGIUM Organization address address: RUE EDOUARD BELIN 5 city: MONT SAING GUIBERT postcode: 1435 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (MONT SAING GUIBERT)	participant	89˙152.00
16	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	88˙672.00
17	UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Organization address address: Langenbeckstrasse 1 city: Mainz postcode: 55131 website: http://www.um-mainz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Mainz)	participant	60˙000.00
18	ABBVIE INC ABBVIE INC Organization address address: NORTH WAUKEGAN ROAD 1 city: NORTH CHICAGO IL postcode: 60064 website: www.abbvie.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NORTH CHICAGO IL)	participant	0.00
19	ARLENDA SA ARLENDA SA Organization address address: RUE EDOUARD BELIN 5 city: MONT-SAINT-GUIBERT postcode: 1435 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (MONT-SAINT-GUIBERT)	participant	0.00
20	BOEHRINGER INGELHEIM INTERNATIONALGMBH BOEHRINGER INGELHEIM INTERNATIONALGMBH Organization address address: BINGER STRASSE city: INGELHEIM postcode: 55218 website: www.boehringerâ€ingelheim.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (INGELHEIM)	participant	0.00
21	F. HOFFMANN-LA ROCHE AG F. HOFFMANN-LA ROCHE AG Organization address address: GRENZACHERSTRASSE 124 city: BASEL postcode: 4070 website: www.roche.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
22	INSTITUT DE RECHERCHES SERVIER INSTITUT DE RECHERCHES SERVIER Organization address address: 3 Rue de la Republique city: SURESNES postcode: 92150 website: www.servier.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SURESNES)	participant	0.00
23	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	0.00
24	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
25	ORION OYJ ORION OYJ Organization address address: ORIONINTIE 1 city: ESPOO postcode: 2200 website: http://www.orion.fi/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	participant	0.00
26	PFIZER LIMITED PFIZER LIMITED Organization address address: RAMSGATE ROAD city: SANDWICH postcode: CT13 9NJ website: www.pfizer.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SANDWICH)	participant	0.00
27	PSYCHOGENICS INC PSYCHOGENICS INC Organization address address: 765 OLD SAW MILL RIVER ROAD city: TARRYTOWN postcode: NY10591 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (TARRYTOWN)	participant	0.00
28	SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT Organization address address: Pierre Brossolette 1 city: Chilly Mazarin postcode: 91380 website: www.sanofi-aventis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Chilly Mazarin)	participant	0.00
29	SCIENCE EXCHANGE, INC. SCIENCE EXCHANGE, INC. Organization address address: 203 FOREST AVE city: PALO ALTO postcode: 94301 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (PALO ALTO)	participant	0.00
30	UCB BIOPHARMA SRL UCB BIOPHARMA SRL Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: www.ucb.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	0.00

Map

Project objective

Pharmaceutical industry, as well as basic science, depend on robust data and scientific rigor as key drivers for decision making, patent strength and time-to-market, which in turn will determine knowledge gain and availability of new treatments to patients. Recent publications report challenges with the robustness, rigor, and/or validity of research data, which may impact decisions about whether to proceed to preclinical and clinical testing as well as conclusions on the predictability of preclinical models. There is a need for simple, sustainable solutions that facilitate data quality. We will propose simple, sustainable solutions that facilitate data quality without impacting innovation and freedom of research. Our consortium will pool resources from both academia and industry to pilot this action in Neuroscience and Safety, but with applicability beyond these R&D areas. The European Quality In Preclinical Data (EQIPD) consortium will (i) define those variables in study design and data analysis that influence outcome in pre-clinical neuroscience (focus on Alzheimer’s disease and psychosis) and (neuro-)safety studies conducted in industry; and establish whether these are the same variables which influence outcome in academia; (ii) define the components which will make up the EQIPD quality management system; (iii) define consensus quality management recommendations for non-regulated R&D; (iv) validate the feasibility of the quality management system in prospective studies; (v) deliver an online educational platform providing certified education and training in the principles and application of quality and rigour. We will use systematic review and meta-analysis of historical data sets from industry and academia to identify variables of study design which determine outcomes in preclinical studies. Informed by the outcome of these analyses, we will use a Delphi approach to reach consensus around core principles for preclinical robustness, validate these approaches in cross site experiments and establish ring testing experiments in non-regulated research. We will develop a quality system framework to attest to compliance and a governance system to ensure sustainability and relevance. We will develop an educational platform to ensure research community-wide expansion of knowledge on criteria and principles necessary to address robustness and quality. Junior researchers are involved in many of the tasks and are enrolled in an academia/industry joint exchange scheme. They will form the core from where a cultural change should emerge in form of a ripple effect. Consortium members have made pivotal scientific and policy contributions relating to the robustness, rigor and validity of pre-clinical research in the past and together have the know-how and infrastructure necessary to succeed in this highly ambitious project.

Deliverables

List of deliverables.
Structure and first incentives for electronic community enabling social learning, hosted on a web-based platform	Other	2020-04-09 02:16:09
With input from WPs 2 and 3 develop harmonized protocols for cross validation testing	Documents, reports	2020-04-09 02:16:09
Evaluation of existing training modules	Documents, reports	2020-04-09 02:16:09
Outcome report from cross site validation	Documents, reports	2020-04-09 02:16:09
Data inclusion protocol	Open Research Data Pilot	2020-04-09 02:16:09
Release of project website public and internal part, communication package (logo, flyer, social media announcement	Websites, patent fillings, videos etc.	2020-04-09 02:16:09
1st Technical diagram of EQIPD-DWH	Other	2020-04-09 02:16:09
Obtain ethical approval for cross-site validation studies and ring testing	Documents, reports	2020-04-09 02:16:09
First quarterly electronic bulletins online	Websites, patent fillings, videos etc.	2020-04-09 02:16:09
First press release	Websites, patent fillings, videos etc.	2020-04-09 02:16:09

Take a look to the deliverables list in detail: detailed list of EQIPD deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Martin C. Michel, T.J. Murphy, Harvey J. Motulsky New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology published pages: 64-74, ISSN: 0090-9556, DOI: 10.1124/dmd.119.090027	Drug Metabolism and Disposition 48/1	2020-04-09
2019	Martin C. Michel, T.J. Murphy, Harvey J. Motulsky New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology published pages: 136-147, ISSN: 0022-3565, DOI: 10.1124/jpet.119.264143	Journal of Pharmacology and Experimental Therapeutics 372/1	2020-04-09
2019	Marjan Amiri, Sandra Murgas, Andreas Stang, Martin C. Michel Do overactive bladder symptoms and their treatmentâ€associated changes exhibit a normal distribution? Implications for analysis and reporting published pages: 754-761, ISSN: 0733-2467, DOI: 10.1002/nau.24275	Neurourology and Urodynamics 39/2	2020-04-09
2019	Anton Bespalov, Thomas Steckler, Phil Skolnick Be positive about negativesâ€“recommendations for the publication of negative (or null) results published pages: 1312-1320, ISSN: 0924-977X, DOI: 10.1016/j.euroneuro.2019.10.007	European Neuropsychopharmacology 29/12	2020-04-09
2019	Martin C. Michel, T.J. Murphy, Harvey J. Motulsky New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology published pages: 49-60, ISSN: 0026-895X, DOI: 10.1124/mol.119.118927	Molecular Pharmacology 97/1	2020-04-09
2020	Betul R. Erdogan, Irem Karaomerlioglu, Zeynep E. Yesilyurt, Nihal Ozturk, A. Elif Muderrisoglu, Martin C. Michel, Ebru Arioglu-Inan Normalization of organ bath contraction data for tissue specimen size: does one approach fit all? published pages: 243-251, ISSN: 0028-1298, DOI: 10.1007/s00210-019-01727-x	Naunyn-Schmiedeberg\'s Archives of Pharmacology 393/2	2020-04-09
2018	Steckler, T., Macleod, M., Kas, M. J. H., Gilis, A., & Wever, K. E. European Quality in Preclinical Data (EQIPD): Een breed consortium voor het verbeteren van de kwaliteit van proefdieronderzoek. published pages: 18-23, ISSN: 0166-6207, DOI:	Biotechniek 57 (2)	2020-04-09
2018	Harvey J Motulsky, Martin C Michel Commentary on the BJP \'s new statistical reporting guidelines published pages: 3636-3637, ISSN: 0007-1188, DOI: 10.1111/bph.14441	British Journal of Pharmacology 175/18	2020-04-09
2018	Jan Vollert, Esther Schenker, Malcolm Macleod, Anton Bespalov, Hanno Wuerbel, Martin Christian Michel, Ulrich Dirnagl, Heidrun Potschka, Kimberley E Wever, Thomas Steckler, Bruce Altevogt, Andrew S C Rice Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals published pages: e000004, ISSN: 2398-8703, DOI: 10.1136/bmjos-2018-000004	BMJ Open Science 2/1	2020-04-09

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