Explore the words cloud of the EQIPD project. It provides you a very rough idea of what is the project "EQIPD" about.
The following table provides information about the project.
Coordinator |
THE UNIVERSITY OF EDINBURGH
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://www.eqipd.org |
Total cost | 9˙845˙483 € |
EC max contribution | 4˙495˙523 € (46%) |
Programme |
1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2)) |
Code Call | H2020-JTI-IMI2-2016-09-two-stage |
Funding Scheme | IMI2-RIA |
Starting year | 2017 |
Duration (year-month-day) | from 2017-10-01 to 2020-09-30 |
Take a look of project's partnership.
Pharmaceutical industry, as well as basic science, depend on robust data and scientific rigor as key drivers for decision making, patent strength and time-to-market, which in turn will determine knowledge gain and availability of new treatments to patients. Recent publications report challenges with the robustness, rigor, and/or validity of research data, which may impact decisions about whether to proceed to preclinical and clinical testing as well as conclusions on the predictability of preclinical models. There is a need for simple, sustainable solutions that facilitate data quality. We will propose simple, sustainable solutions that facilitate data quality without impacting innovation and freedom of research. Our consortium will pool resources from both academia and industry to pilot this action in Neuroscience and Safety, but with applicability beyond these R&D areas. The European Quality In Preclinical Data (EQIPD) consortium will (i) define those variables in study design and data analysis that influence outcome in pre-clinical neuroscience (focus on Alzheimer’s disease and psychosis) and (neuro-)safety studies conducted in industry; and establish whether these are the same variables which influence outcome in academia; (ii) define the components which will make up the EQIPD quality management system; (iii) define consensus quality management recommendations for non-regulated R&D; (iv) validate the feasibility of the quality management system in prospective studies; (v) deliver an online educational platform providing certified education and training in the principles and application of quality and rigour. We will use systematic review and meta-analysis of historical data sets from industry and academia to identify variables of study design which determine outcomes in preclinical studies. Informed by the outcome of these analyses, we will use a Delphi approach to reach consensus around core principles for preclinical robustness, validate these approaches in cross site experiments and establish ring testing experiments in non-regulated research. We will develop a quality system framework to attest to compliance and a governance system to ensure sustainability and relevance. We will develop an educational platform to ensure research community-wide expansion of knowledge on criteria and principles necessary to address robustness and quality. Junior researchers are involved in many of the tasks and are enrolled in an academia/industry joint exchange scheme. They will form the core from where a cultural change should emerge in form of a ripple effect. Consortium members have made pivotal scientific and policy contributions relating to the robustness, rigor and validity of pre-clinical research in the past and together have the know-how and infrastructure necessary to succeed in this highly ambitious project.
Structure and first incentives for electronic community enabling social learning, hosted on a web-based platform | Other | 2020-04-09 02:16:09 |
With input from WPs 2 and 3 develop harmonized protocols for cross validation testing | Documents, reports | 2020-04-09 02:16:09 |
Evaluation of existing training modules | Documents, reports | 2020-04-09 02:16:09 |
Outcome report from cross site validation | Documents, reports | 2020-04-09 02:16:09 |
Data inclusion protocol | Open Research Data Pilot | 2020-04-09 02:16:09 |
Release of project website public and internal part, communication package (logo, flyer, social media announcement | Websites, patent fillings, videos etc. | 2020-04-09 02:16:09 |
1st Technical diagram of EQIPD-DWH | Other | 2020-04-09 02:16:09 |
Obtain ethical approval for cross-site validation studies and ring testing | Documents, reports | 2020-04-09 02:16:09 |
First quarterly electronic bulletins online | Websites, patent fillings, videos etc. | 2020-04-09 02:16:09 |
First press release | Websites, patent fillings, videos etc. | 2020-04-09 02:16:09 |
Take a look to the deliverables list in detail: detailed list of EQIPD deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Martin C. Michel, T.J. Murphy, Harvey J. Motulsky New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology published pages: 64-74, ISSN: 0090-9556, DOI: 10.1124/dmd.119.090027 |
Drug Metabolism and Disposition 48/1 | 2020-04-09 |
2019 |
Martin C. Michel, T.J. Murphy, Harvey J. Motulsky New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology published pages: 136-147, ISSN: 0022-3565, DOI: 10.1124/jpet.119.264143 |
Journal of Pharmacology and Experimental Therapeutics 372/1 | 2020-04-09 |
2019 |
Marjan Amiri, Sandra Murgas, Andreas Stang, Martin C. Michel Do overactive bladder symptoms and their treatmentâ€associated changes exhibit a normal distribution? Implications for analysis and reporting published pages: 754-761, ISSN: 0733-2467, DOI: 10.1002/nau.24275 |
Neurourology and Urodynamics 39/2 | 2020-04-09 |
2019 |
Anton Bespalov, Thomas Steckler, Phil Skolnick Be positive about negatives–recommendations for the publication of negative (or null) results published pages: 1312-1320, ISSN: 0924-977X, DOI: 10.1016/j.euroneuro.2019.10.007 |
European Neuropsychopharmacology 29/12 | 2020-04-09 |
2019 |
Martin C. Michel, T.J. Murphy, Harvey J. Motulsky New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology published pages: 49-60, ISSN: 0026-895X, DOI: 10.1124/mol.119.118927 |
Molecular Pharmacology 97/1 | 2020-04-09 |
2020 |
Betul R. Erdogan, Irem Karaomerlioglu, Zeynep E. Yesilyurt, Nihal Ozturk, A. Elif Muderrisoglu, Martin C. Michel, Ebru Arioglu-Inan Normalization of organ bath contraction data for tissue specimen size: does one approach fit all? published pages: 243-251, ISSN: 0028-1298, DOI: 10.1007/s00210-019-01727-x |
Naunyn-Schmiedeberg\'s Archives of Pharmacology 393/2 | 2020-04-09 |
2018 |
Steckler, T., Macleod, M., Kas, M. J. H., Gilis, A., & Wever, K. E. European Quality in Preclinical Data (EQIPD): Een breed consortium voor het verbeteren van de kwaliteit van proefdieronderzoek. published pages: 18-23, ISSN: 0166-6207, DOI: |
Biotechniek 57 (2) | 2020-04-09 |
2018 |
Harvey J Motulsky, Martin C Michel Commentary on the BJP \'s new statistical reporting guidelines published pages: 3636-3637, ISSN: 0007-1188, DOI: 10.1111/bph.14441 |
British Journal of Pharmacology 175/18 | 2020-04-09 |
2018 |
Jan Vollert, Esther Schenker, Malcolm Macleod, Anton Bespalov, Hanno Wuerbel, Martin Christian Michel, Ulrich Dirnagl, Heidrun Potschka, Kimberley E Wever, Thomas Steckler, Bruce Altevogt, Andrew S C Rice Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals published pages: e000004, ISSN: 2398-8703, DOI: 10.1136/bmjos-2018-000004 |
BMJ Open Science 2/1 | 2020-04-09 |
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The information about "EQIPD" are provided by the European Opendata Portal: CORDIS opendata.
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