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cureCD SIGNED

Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis

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EC-Contrib. €

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Partnership

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 cureCD project word cloud

Explore the words cloud of the cureCD project. It provides you a very rough idea of what is the project "cureCD" about.

expand    outcomes    inflammatory    utilize    disease    ve    individuals    exploration    off    interaction    dysregulation    lncrna    minimal    epithelial    core    intervention    half    microbiome    relative    strategies    prospectively    opposing    patients    understand    informatics    nodes    intestinal    carries    ibd    million    rnaseq    ulcerative    crohn    protein    regulate    cellular    mrnaseq    renewal    tissue    granulocytes    central    na    diseases    co    exhibit    ulcers    lab    human    expression    gut    culture    coding    plan    suppress    rnas    conserved    tissues    therapeutic    treatment    guide    mucosal    failed    diverse    cd    genes    colitis    model    ileum    regarding    contexts    experimental    worldwide    ulcer    pediatric    attempts    critical    prospective    deleterious    importently    microbiota    six    collected    functions    bowel    epithelia    limited    healing    carful    interactions    function    chronic    correlations    hallmark    cells    relapsing    uc    explore    pathogenesis    mechanistic    mediating    profiles    immune    iuml    disorders    biopsies   

Project "cureCD" data sheet

The following table provides information about the project.

Coordinator		 MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER 

Organization address
address: TEL HASHOMER SHEBA MEDICAL CENTER
city: RAMAT GAN
postcode: 52621
website: http://www.sheba.co.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER IL (RAMAT GAN) coordinator 1˙500˙000.00

Map

 Project objective

The Inflammatory Bowel Diseases (IBD), Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic/relapsing disorders that affect over six million individuals worldwide. Mucosal ulcers, the hallmark of CD, are the result of a complex interaction between microbiota, immune cells, and gut epithelia. Healing of mucosal ulcers is associated with better outcomes, but is achieved in less than half of cases. Past attempts to suppress central and conserved nodes of the immune system failed due to opposing off-target deleterious effects on epithelial renewal. Therefore, there is a critical need to identify more tissue specific targets that lead to mucosal healing and to improved outcomes.

Using mRNAseq of intestinal biopsies, we identified a widespread dysregulation of long non-coding RNAs (lncRNA) in the ileum of treatment naïve pediatric CD patients. Importently, we identified significant correlations between lncRNA and mucosal ulcers. CD lncRNA, after carful mechanistic exploration, are highly promising targets for potential future intervention as they regulate diverse cellular functions and exhibit a more tissue specific expression in comparison to protein coding genes. The core goal of this proposal is to understand the role of CD lncRNA in ulcer pathogenesis focusing on granulocytes and epithelial functions in the contexts of their interactions with the microbiota.

I plan to utilize state of the art informatics, RNAseq and microbiome profiles together with advanced and novel experimental lab model and co-culture systems, patients-derived prospectively collected tissues, and gut microbiota to explore the role of CD lncRNA function in mediating healing of mucosal ulcers. This work carries the potential to guide new novel therapeutic strategies for mucosal healing with minimal off-targets effects. In a broader prospective, this work will expand our relative limited understanding regarding the role of lncRNA in mediating human diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J. Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-He
Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis
published pages: 491-502, ISSN: 1933-0219, DOI: 10.1038/s41385-018-0114-4 		Mucosal Immunology 12/2 2020-02-13
2019 Nurit Loberman-Nachum, Katya Sosnovski, Ayelet Di Segni, Gilat Efroni, Tzipi Braun, Marina BenShoshan, Lait Anafi, Camila Avivi, Iris Barshack, Dror S. Shouval, Lee A. Denson, Amnon Amir, Ron Unger, Batia Weiss, Yael Haberman
Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-52733-1 		Scientific Reports 9/1 2020-02-13

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The information about "CURECD" are provided by the European Opendata Portal: CORDIS opendata.

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