MULTICELL
Microfluidic multiplexed cell chips
| Coordinatore | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 1˙494˙744 € |
| EC contributo | 1˙494˙744 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2011-StG_20101014 |
| Funding Scheme | ERC-SG |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-02-01 - 2017-01-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | hostInstitution | 1˙494˙744.00 |
| 2 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | hostInstitution | 1˙494˙744.00 |
Mappa
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Obiettivo del progetto (Objective)
'There exist very few techniques for studying a group of cells containing a large number compared to a single cell but small compared to a whole tissue. This implies that statistics are exceedingly difficult to obtain from measurements of individual cells. Microfluidics provides a way to amend this by allowing ways to observe individual cells and automate such measurements. The aim in this project is to develop a cell manipulation platforms based on microfluidics techniques developed in our lab, while answering relevant biological questions.
The first question concerns Sickle Cell Anemia, a genetic disease for which no treatment exists. We will study the polymerization of hemoglobin within red blood cells, as they are submitted to cycles of oxygenation and deoxygenation. Quantitative measurements of the response of the cells to oxygen variations will allow physiological conditions to be simulated, including in the presence of therapeutic candidates or other biological agents.
The second question concerns the motility of adherent cells in a three-dimensional environment. This question will be to understand the migration of cells in a 3D gradient of chemo-attractant, as well as gradients of rigidity of the environment. This part will require the development of new technological tools which can later be applied to a wide range of biological problems. The long term aim is to replace the current tools of biological labs with miniaturized and integrated lab on a chip devices.'