THE GRAIL
Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer
| Coordinatore | EXPLORA SRL
Organization address
address: Via Giacomo Peroni 386 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 7˙804˙024 € |
| EC contributo | 5˙998˙438 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2011-two-stage |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-01-01 - 2016-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
EXPLORA SRL
Organization address
address: Via Giacomo Peroni 386 contact info |
IT (ROMA) | coordinator | 1˙436˙920.00 |
| 2 |
THE UNIVERSITY OF LIVERPOOL
Organization address
address: Brownlow Hill, Foundation Building 765 contact info |
UK (LIVERPOOL) | participant | 885˙600.00 |
| 3 |
UNIVERSIDAD DE VALLADOLID
Organization address
address: PLAZA SANTA CRUZ 8 PALACIO DE SANTA CRUZ contact info |
ES (VALLADOLID) | participant | 787˙800.00 |
| 4 |
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 contact info |
ES (BARCELONA) | participant | 681˙120.00 |
| 5 |
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Organization address
address: Corso Umberto I 40 contact info |
IT (NAPOLI) | participant | 675˙440.00 |
| 6 |
"CONIC VASCULAR TECHNOLOGY, S.A."
Organization address
address: "VIA G. CURTI, 5" contact info |
CH (LUGANO) | participant | 596˙300.00 |
| 7 |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Organization address
address: HEIDELBERGLAAN 100 contact info |
NL (UTRECHT) | participant | 430˙318.00 |
| 8 |
DONAWA LIFESCIENCE CONSULTING SRL
Organization address
address: PIAZZA ALBANIA 10 contact info |
IT (ROMA) | participant | 275˙000.00 |
| 9 |
TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
Organization address
address: PASEO DE BELEN 11 contact info |
ES (VALLADOLID) | participant | 229˙940.00 |
Mappa
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Obiettivo del progetto (Objective)
'The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue. The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology.'