THE GRAIL

Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer

Coordinatore	EXPLORA SRL    more  Organization address address: Via Giacomo Peroni 386 city: ROMA postcode: 131 contact info Titolo: Dr. Nome: Davide Cognome: De Lucrezia Email: send email Telefono: +39 041 50 93 865 Fax: +39 041 50 93 881
Nazionalità Coordinatore	Italy [IT]
Totale costo	7˙804˙024 €
EC contributo	5˙998˙438 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-two-stage
Funding Scheme	CP-FP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	EXPLORA SRL  Organization address address: Via Giacomo Peroni 386 city: ROMA postcode: 131 contact info Titolo: Dr. Nome: Davide Cognome: De Lucrezia Email: send email Telefono: +39 041 50 93 865 Fax: +39 041 50 93 881	IT (ROMA)	coordinator	1˙436˙920.00
2	THE UNIVERSITY OF LIVERPOOL  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Ms. Nome: Pam Cognome: Neagle Email: send email Telefono: 441518000000 Fax: 441518000000	UK (LIVERPOOL)	participant	885˙600.00
3	UNIVERSIDAD DE VALLADOLID  Organization address address: PLAZA SANTA CRUZ 8 PALACIO DE SANTA CRUZ city: VALLADOLID postcode: 47002 contact info Titolo: Prof. Nome: José Carlos Cognome: Rodriguez Cabello Email: send email Telefono: 34983184585 Fax: 34983184698	ES (VALLADOLID)	participant	787˙800.00
4	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA  Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 contact info Titolo: Prof. Nome: Planell Cognome: Josep A. Email: send email Telefono: 34934031145 Fax: 34934039702	ES (BARCELONA)	participant	681˙120.00
5	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.  Organization address address: Corso Umberto I 40 city: NAPOLI postcode: 80138 contact info Titolo: Prof. Nome: Paolo Cognome: Netti Email: send email Telefono: 390818000000 Fax: 390818000000	IT (NAPOLI)	participant	675˙440.00
6	"CONIC VASCULAR TECHNOLOGY, S.A."  Organization address address: "VIA G. CURTI, 5" city: LUGANO postcode: 6901 contact info Titolo: Ms. Nome: Nella Cognome: Reina Email: send email Telefono: 41919107788 Fax: 41919239119	CH (LUGANO)	participant	596˙300.00
7	UNIVERSITAIR MEDISCH CENTRUM UTRECHT  Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX contact info Titolo: Dr. Nome: Pieter J.A. Cognome: De Koning Email: send email Telefono: 31887559883 Fax: 31887555459	NL (UTRECHT)	participant	430˙318.00
8	DONAWA LIFESCIENCE CONSULTING SRL  Organization address address: PIAZZA ALBANIA 10 city: ROMA postcode: 153 contact info Titolo: Dr. Nome: Maria Elena Cognome: Donawa Email: send email Telefono: 39065782665 Fax: 39065743786	IT (ROMA)	participant	275˙000.00
9	TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL  Organization address address: PASEO DE BELEN 11 city: VALLADOLID postcode: 47011 contact info Titolo: Dr. Nome: Alessandra Cognome: Girotti Email: send email Telefono: 34629864862	ES (VALLADOLID)	participant	229˙940.00

Mappa

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 Obiettivo del progetto (Objective)

'The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue. The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology.'