Coordinatore | CELLON SA
Organization address
address: RUE HEIERCHEN 16 ZAE ROBERT STEICHEN contact info |
Nazionalità Coordinatore | Luxembourg [LU] |
Totale costo | 1˙425˙790 € |
EC contributo | 1˙065˙574 € |
Programma | FP7-SME
Specific Programme "Capacities": Research for the benefit of SMEs |
Code Call | FP7-SME-2012 |
Funding Scheme | BSG-SME |
Anno di inizio | 2012 |
Periodo (anno-mese-giorno) | 2012-11-01 - 2014-10-31 |
# | ||||
---|---|---|---|---|
1 |
CELLON SA
Organization address
address: RUE HEIERCHEN 16 ZAE ROBERT STEICHEN contact info |
LU (BASCHARAGE) | coordinator | 416˙470.00 |
2 |
DTL BIOTECHNOLOGY LIMITED
Organization address
address: CLARA ROAD CARRAIG CLUAIN 107 contact info |
IE (TULLAMORE) | participant | 390˙396.00 |
3 |
SILICONE-ALTIMEX LIMITED
Organization address
address: PASTURE ROAD STAPLEFORD 49 contact info |
UK (NOTTINGHAM) | participant | 244˙308.00 |
4 |
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Organization address
address: Av. da Republica, Quinta do Marques S/N contact info |
PT (OEIRAS) | participant | 5˙200.00 |
5 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Organization address
address: BELFIELD contact info |
IE (DUBLIN) | participant | 5˙200.00 |
6 |
InSCREENeX GmbH
Organization address
address: INHOFFENSTRASSE 7 contact info |
DE (BRAUNSCHWEIG) | participant | 4˙000.00 |
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'Silicone if combined with appropriate cell adherent regulatory compounds offers significant advantages as a micro cell carrier, effectively a 3D microtissue device. These benefits include a capacity for defined and controlled porosity, inner chamber size, density, flexible shape, friction resistant, and low toxicity. The lead SME partner holds the IP for a silicone cell carrier device, which met some of these criteria, but exhibited poor cell adherence and requires re-engineering and exploitation of current cell molecular knowledge. There is a strong commercial need for such fully functional 3D cell culture technologies (microtissue) that can be manufactured into robust and reproducible in vitro test systems for toxicity testing, drug testing, cosmetic testing as part of a projected €1.6b cell based test market. This device may also eventually function as an active component in bioartificial livers (BAL) and other organ devices. The market growth is driven by needs in drug screening for drug discovery and toxicity screening. There are also a number of current EU directives that is driving the demand for reliable in vitro 3D cell based test system to replace in vivo test systems. The bio artificial liver market is also expected to grow rapidly due to high rates of liver disease worldwide. This project will develop novel develop new 3D cell culture technology based on proprietary cell immortalisation and the owned cell immobilisation technology. The objectives will be to deliver: 1) Immortalised hepatocyte and endothelial cells that retain characteristics of primary liver cells in 3D co-culture. 2) A porous silicone carrier for 3D culture 3) A scaleable bioreactor systems for 3D culture The following products will be developed using this technology, 1) 3D liver cell multiwell plate assay system, 2) 3D liver microbioreactor system and 3) a bioreactor component for a BAL device. Minimal SME economic return is predicted at €12m within 3 years of project completion'
Researchers are developing 3D cell-culture technology for growing bio-artificial livers, as well as artificial liver systems to test drug toxicity.
Silicone is a good potential scaffold for growing artificial organs and 3D microtissue devices. However, further work is required to improve cell adherence and optimise various 3D microtissue systems for commercial application.
The 'Specialised cell carrier components' (http://www.biospeccc.com (SPECCC)) project builds on previous work on this system carried out at one of the project's industrial partner companies. The project is now developing several different systems using liver cells and a silicone framework.Researchers investigated the growth of liver cells in the first-generation silicone carriers. This initial work also looked into growing liver cells in carriers in bioreactors.
Project members have also made progress towards developing the liver cell lines required for the biological aspect of these systems. They have immortalised hepatocytes (liver cells) and liver endothelial cells from humans for this purpose.
SPECCC has also worked on the physical properties of the porous silicone carrier, such as pore volume, mechanical stability and cell surface properties. Researchers have tested plasma and collagen treatments of the silicone surface to help liver cells stick.The project will use this research to build prototype second-generation silicone carriers. These will have applications in drug and toxicity testing.
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