EPIHEALTHNET

EpiHealthNet

Coordinatore	UNIVERSITEIT UTRECHT    more  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Prof. Nome: Andras Cognome: Dinnyes Email: send email Telefono: +31 30 253 90 00 Fax: +31 30 253 77 27
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	3˙660˙256 €
EC contributo	3˙660˙256 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-ITN
Funding Scheme	MC-ITN
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-05-01   -   2017-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Prof. Nome: Andras Cognome: Dinnyes Email: send email Telefono: +31 30 253 90 00 Fax: +31 30 253 77 27	NL (UTRECHT)	coordinator	868˙647.10
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Prof. Nome: Anne Cognome: Ferguson-Smith Email: send email Telefono: +44 1223 333834 Fax: +44 1223 332988	UK (CAMBRIDGE)	participant	572˙313.25
3	SZENT ISTVAN UNIVERSITY  Organization address address: Pater Karoly utca 1 city: GODOLLO postcode: 2100 contact info Titolo: Prof. Nome: Andras Cognome: Dinnyes Email: send email Telefono: +36 20 5109632 Fax: +36 28 526151	HU (GODOLLO)	participant	395˙061.03
4	BIOTALENTUM TUDASFEJLESZTO KFT  Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 contact info Titolo: Dr. Nome: Ildiko Cognome: Nagy Email: send email Telefono: +36 20 2750933 Fax: +36 28 526243	HU (GOEDOELLO)	participant	366˙678.40
5	AVANTEA srl  Organization address address: via Cabrini 12 city: Cremona postcode: 26100 contact info Titolo: Dr. Nome: Giovanna Cognome: Lazzari Email: send email Telefono: +39 0372 437242 Fax: +39 0372 436133	IT (Cremona)	participant	345˙705.60
6	MWM BIOMODELS GMBH  Organization address address: HAUPTSTRASSE 41 city: TIEFENBACH postcode: 84184 contact info Titolo: Dr. Nome: Christian Cognome: Simmet Email: send email Telefono: +49 8709 9229 0 Fax: +49 8709 9229 39	DE (TIEFENBACH)	participant	318˙019.25
7	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Dr. Nome: Katherine Cognome: Boylan Email: send email Telefono: +44 161 275 8796 Fax: +44 161 2752445	UK (MANCHESTER)	participant	285˙606.62
8	UNIVERSITY OF SOUTHAMPTON  Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ contact info Titolo: Prof. Nome: Tom Cognome: Fleming Email: send email Telefono: +44 23 80 79 41 45	UK (SOUTHAMPTON)	participant	285˙606.62
9	MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG  Organization address address: UNIVERSITAETSPLATZ 10 city: HALLE (Saale) postcode: 6099 contact info Titolo: Ms. Nome: Peggy Cognome: Patzner Email: send email Telefono: +49 345 5574453 Fax: +49 345 5574452	DE (HALLE (Saale))	participant	222˙618.88

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient delivery to the needs of the developing fetus. EpiHealth will focus on these early events in several relevant models(diabetes, obesity and assisted reproductive technologies (ART)),using human samples, stem cell lines, animal models and data mining/bioinformatics tools to decipher some of the most important pathways and to offer options for early intervention to avoid adverse health effects. Main goal of the project is to improve health of the human population by understanding the mechanisms and pathways in early development, with special emphasis on epigenetic changes and developmentally relevant metabolic signalling, which create biological variation and have a long term effect on the health of individuals across the lifespan. Specific goals include: i)Identification of the main genetic pathways affecting the health of the developing embryos in a diabetic or obese maternal environment; ii) Identification of the main genetic and metabolic pathways affected and epigenomic and imprinting perturbations from mouse and human ART resulting in altered health of the progeny; iii)Discovery of the key genes and pathways affecting epigenetic and imprinting sensitivity in early stages of development in order to create intervention tools against epigenetic mis-programming; iv)Linking for the first time by bioinformatics tools the longevity related pathways and those susceptible to early epigenetic perturbations in order to explain how early events influence the health and lifespan of individuals; v)Studying the possibilities of early intervention by controlling the maternal environment.'