HYPORTH
New approaches in the development of Hypoallergenic implant material in Orthopaedics: steps to personalised medicine
| Coordinatore | OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Organization address
address: UNIVERSITAETSPLATZ 2 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 7˙201˙662 € |
| EC contributo | 5˙282˙600 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-08-01 - 2018-07-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG
Organization address
address: UNIVERSITAETSPLATZ 2 contact info |
DE (MAGDEBURG) | coordinator | 1˙350˙807.00 |
| 2 |
TARTU ULIKOOL
Organization address
address: ULIKOOLI 18 contact info |
EE (TARTU) | participant | 900˙000.00 |
| 3 |
PROGENIKA BIOPHARMA SA
Organization address
address: "Parque Tecnologico de Zamudio, Edificio 801 -A-, Planta 2" contact info |
ES (DERIO - VIZCAYA) | participant | 750˙928.00 |
| 4 |
RESEARCH CENTRE FOR NATURAL SCIENCES, HUNGARIAN ACADEMY OF SCIENCES
Organization address
address: PUSZTASZERI UTCA 59-67 contact info |
HU (BUDAPEST) | participant | 709˙999.00 |
| 5 |
MATHYS AG BETTLACH
Organization address
address: ROBERT MATHYS STRASSE 5 contact info |
CH (BETTLACH) | participant | 455˙199.00 |
| 6 |
INSTYTUT OBROBKI PLASTYCZNEJ
Organization address
address: Jana Pawla II 14 contact info |
PL (Poznan) | participant | 404˙291.00 |
| 7 |
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O
Organization address
address: Oskar-von-Miller-Ring 29 contact info |
DE (MUENCHEN) | participant | 400˙000.00 |
| 8 |
TEKNOLOGISK INSTITUT
Organization address
address: GREGERSENSVEJ 1 contact info |
DK (TAASTRUP) | participant | 311˙376.00 |
| 9 |
MAGYAR TUDOMANYOS AKADEMIA ENERGIATUDOMANYI KUTATOKOZPONT
Organization address
address: KONKOLY THEGE MIKLOS UT 29-33 contact info |
HU (Budapest) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Europe is confronted by a demographic challenge as a decreasing work force has to support an increasing elderly population. The economic risk implied by this burden could be addressed by efforts to achieve an increase in Healthy Life Years. One key element would be to ensure unrestricted mobility for especially the elderly, allowing them to stay at work for longer. Irreversible joint deterioration often requires a joint replacement. Implantation of artificial joints is one of the most successful orthopaedic interventions. However, an increasing number of patients receive revision surgery with these 10 % of these contract an infection and 50 % develop an adverse immune reaction (AIR) to conventional implant material. At the moment the reasons for the development of AIR are inadequately understood. Our proposal contains innovative solutions concerning this problem. A predictive approach using biomarkers will identify patients with risk to develop AIR. These patients will receive hypoallergenic endoprostheses, avoiding AIR to conventional material. Novel hypoallergenic material combinations will be developed in the frame of this consortium by material scientists and implant manufacturer. Via immunological, microbiological and biocompatibility testing the development and production process will be improved constantly. The matching of implant material with the allergenic background of patients will avoid complicated and cost-intensive reverse reactions and is a step towards personalised medicine. A further approach is to achieve a better understanding of mechanisms of AIR, and its faster and easier diagnosis using sensitive diagnostic biomarkers for an accurate differentiation from low-grade infection. Additionally, mathematical modelling of results from different methods will show us the gene regulatory network that leads to an amplification of the adverse immune response triggered by prosthetic implants and will develop predictive models of AIR process.'