FIBRO-TARGETS

Targeting cardiac fibrosis for heart failure treatment

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)    more  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Marie-Ange Cognome: Luc Email: send email Telefono: +33 3 88 10 86 56 Fax: +33 3 88 10 8175
Nazionalità Coordinatore	France [FR]
Sito del progetto	http://www.fibrotargets.eu
Totale costo	8˙178˙399 €
EC contributo	6˙000˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2017-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)  Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Marie-Ange Cognome: Luc Email: send email Telefono: +33 3 88 10 86 56 Fax: +33 3 88 10 8175	FR (PARIS)	coordinator	1˙050˙010.00
2	FIRALIS S.A.S.  Organization address address: Rue du Fort city: Huningue postcode: 68330 contact info Titolo: Ms. Nome: Regine Cognome: Will Email: send email Telefono: +33 389911320 Fax: +33 981708433	FR (Huningue)	participant	960˙000.00
3	MEDIZINISCHE UNIVERSITAET WIEN  Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Gerald Cognome: Maurer Email: send email Telefono: +43 1 40400 4614 Fax: +43 1 40400 4216	AT (WIEN)	participant	680˙000.00
4	FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA  Organization address address: AVENIDA DE PIO XII 55 city: PAMPLONA postcode: 31008 contact info Titolo: Dr. Nome: Andrew Cognome: Solomon Email: send email Telefono: +34 948194700 Fax: 34948194718	ES (PAMPLONA)	participant	600˙000.00
5	MEDIZINISCHE HOCHSCHULE HANNOVER  Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 contact info Titolo: Mr. Nome: Frank Cognome: Dittrich Email: send email Telefono: +49 511 532 5343 Fax: +49 511 532 4253	DE (HANNOVER)	participant	500˙000.00
6	UNIVERSITEIT MAASTRICHT  Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD contact info Titolo: Mr. Nome: Rob Cognome: Van Der Zander Email: send email Telefono: 3143381645	NL (MAASTRICHT)	participant	500˙000.00
7	Innovative Technologies in Biological Systems  Organization address city: Derio postcode: 48160 contact info Titolo: Prof. Nome: Isbaal Cognome: Ramos Email: send email Telefono: +34 944005355 Fax: 34946579925	ES (Derio)	participant	450˙000.00
8	INSERM - TRANSFERT SA  Organization address address: Rue Watt 7 city: PARIS postcode: 75013 contact info Titolo: Mr. Nome: Louis Cognome: Jammayrac Email: send email Telefono: +33 155030101 Fax: +33 155030160	FR (PARIS)	participant	400˙000.00
9	GREENPHARMA S.A.S	FR	participant	390˙000.00
10	FUNDACION PUBLICA MIGUEL SERVET  Organization address address: C/IRUNLARREA 3 city: PAMPLONA postcode: 31008 contact info Titolo: Ms. Nome: Maria Soledad Cognome: Fragoso Email: send email Telefono: +34 848 422607 Fax: +34 848 422200	ES (PAMPLONA)	participant	269˙990.00
11	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Mr. Nome: Donal Cognome: Doolan Email: send email Telefono: +353 1 7161656 Fax: +353 1 7161216	IE (DUBLIN)	participant	200˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'The Fibro-Targets project is a multi-disciplinary 4 years program involving 10 partners ambitioning “the identification, characterisation and validation of in vitro and in vivo models of novel therapeutically relevant targets” for myocardial interstitial fibrosis (MIF) in heart failure. The project is based on the hypothesis that the intervention on novel fibrosis-related targets involved in the processes of fibroblast differentiation to myofibroblasts, the predominance of collagen synthesis over degradation and/or collagen maturation may allow for interstitial repair, thus providing a new strategy for the prevention and treatment of adverse cardiac remodeling involved in the transition to and the progression of heart failure. From a large body of existing multi-omics, literature data and previous hypothesis-driven research conducted by members of the consortium, a number of specific extracellular and intracellular targets have been identified whose involvement in MIF is beginning to be understood and that may be targeted by specific therapies. The specific aims of the Fibro-Targets are: (i) To provide further evidence on the mechanisms of action of the above targets (ii) To validate experimentally that new anti-fibrotic strategies can be developed based on the above targets (iii) To approach the potential clinical scenario of the above targets for HF therapy To reach these aims the following studies will be performed: (i) Observational and interventional experimental studies in already existing and/or de novo generated appropriate in vitro and in vivo models. (ii) Clinical studies, stratifying large scale populations of patients available to the consortium, at risk to develop HF and likely to be responsive to specific novel and/or exiting anti-fibrotic therapies. The stratification will be based on specific “fibrogenetic” phenotypic profiles using multi-panel imaging and circulating markers descriptive of mechanisms involving the proposed novel targets.'