BLADDER CANCER EPID

Nutrition and Bladder Cancer

Coordinatore	UNIVERSITEIT MAASTRICHT    more  Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD contact info Titolo: Mr. Nome: Sef Cognome: Janssen Email: send email Telefono: 31433881961 Fax: 31433670286
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2017-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT MAASTRICHT  Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD contact info Titolo: Mr. Nome: Sef Cognome: Janssen Email: send email Telefono: 31433881961 Fax: 31433670286	NL (MAASTRICHT)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'During the last decade I have built a research line on bladder cancer epidemiology with a specific emphasis on diet. This has led to 54/150 publications on this topic. Although, the literature is sparse, my team and others have concluded that some micronutrients in the diet such as vitamins C, E and selenium may play a preventive role in bladder carcinogenesis. We are currently pursuing this lead with two chemoprevention clinical trials, two case-control and one cohort study. Although other food products have been researched, so far the results remain inconclusive.

Our 2008 expert report for the World Health Organization concluded that the accumulated evidence on the association between specific foods, nutrients, dietary patterns and the risk of bladder cancer is still weak. This is surprising as diet is expected to play an important role in carcinogenesis because the bladder is an excretion organ. The most likely reason for this is that most previous studies have had insufficient sample size and thus lacked adequate statistical power for analyses on 1) individual food items instead of the more common but less detailed food groups, 2) for subgroup analyses and 3) for food-food interactions.

The proposed research brings together the world’s data on diet and bladder cancer. In a unique collaboration, researchers from 26 case-control studies and 15 cohort studies across the world have agreed to share their nutritional data with over 30.000 participants including over 10.000 bladder cancer patients.

The project aims to provide definite answers on which individual food products, nutrients, existing diets (both regionally and culturally defined) and adherence dietary recommendations could influence bladder cancer risk. In addition, contemporary principle components and machine-learning algorithms will be used to identify novel explanatory dietary patterns. The results will be used to update existing dietary recommendations for the prevention of bladder cancer.'