PREGVAX

Plasmodium Vivax Infection in Pregnancy

Coordinatore	FUNDACIO PRIVADA CLINIC PER A LA RECERCA BIOMEDICA    more  Organization address address: CARRER ROSSELLO 149-153 city: BARCELONA postcode: 8029 contact info Titolo: Dr. Nome: Mireia Cognome: Piqueras Email: send email Telefono: +34 93 227 18 51 Fax: +93 227 18 50
Nazionalità Coordinatore	Spain [ES]
Totale costo	3˙928˙460 €
EC contributo	2˙999˙145 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-03-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACIO PRIVADA CLINIC PER A LA RECERCA BIOMEDICA  Organization address address: CARRER ROSSELLO 149-153 city: BARCELONA postcode: 8029 contact info Titolo: Dr. Nome: Mireia Cognome: Piqueras Email: send email Telefono: +34 93 227 18 51 Fax: +93 227 18 50	ES (BARCELONA)	coordinator	0.00
2	CENTRO INTERNACIONAL DE VACUNAS  Organization address address: Carrera 35 4A-53 city: CALI postcode: 25574 contact info Titolo: Ms. Nome: Ruth Cognome: Abello Solis Email: send email Telefono: +57 2 5216231 Fax: +57 2 5560141	CO (CALI)	participant	0.00
3	FUNDACAO DE MEDICINA TROPICAL DO AMAZONES  Organization address address: Av. Pedro Teixeira 25 city: MANAUS postcode: 69040-000 contact info Titolo: Dr. Nome: Silas Cognome: Guedes Email: send email Telefono: +55 92 644 1602 Fax: +55 92 644 1620	BR (MANAUS)	participant	0.00
4	FUNDACION DE LA UNIVERSIDAD DEL VALLE DE GUATEMALA  Organization address address: 18 Calle Vista Hermosa III 15-79 zona 15 Guatemala city: GUATEMALA postcode: 1901 contact info Titolo: Ms. Nome: Maria Eugenia Cognome: López Email: send email Telefono: +502 2364 0336 Fax: +502 2369 7479	GT (GUATEMALA)	participant	0.00
5	INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY  Organization address address: PADRICIANO 99 city: TRIESTE postcode: 34149 contact info Titolo: Ms. Nome: Shubhalakshmi Hariharan Cognome: Narayanan Email: send email Telefono: +91 11 26742356 Fax: +91 11 26742316	IT (TRIESTE)	participant	0.00
6	ISTITUTO SUPERIORE DI SANITA  Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 contact info Titolo: Ms. Nome: Rosa Maria Cognome: Martoccia Email: send email Telefono: +39 06 49902688 Fax: +39 06 49903007	IT (ROMA)	participant	0.00
7	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Christina Cognome: Bergehed-Bonnevier Email: send email Telefono: +46 8 524 871 40 Fax: +46 8 33 97 44	SE (STOCKHOLM)	participant	0.00
8	PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH - PNGIMR  Organization address address: CORNER OF LEIGH VIAL & HOMATE STREETS - GOROKA BASE HOSPITAL GROUNDS TOWN OF GOROKA IN THE EASTERN HIGHLANDS PROVINCE city: GOROKA postcode: 441 contact info Titolo: Mr. Nome: Samson Cognome: Akunaii Email: send email Telefono: +675 732 2800 Fax: +675 732 1998	PG (GOROKA)	participant	0.00
9	RAJASTHAN UNIVERSITY OF HEALTH SCIENCES JAIPUR  Organization address address: TONK ROAD SECTOR 18 KUMBHA MACG city: JAIPUR postcode: 302003 contact info Titolo: Dr. Nome: Swati Cognome: Kochar Email: send email Telefono: +91 151 2523454 Fax: +91 151 2201119	IN (JAIPUR)	participant	0.00

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 Obiettivo del progetto (Objective)

'Malaria in pregnancy has been recently prioritised by the EC 7th Framework Program. In response, we propose to carry out a cohort observational study in pregnant women in 5 P. vivax endemic countries, broadly representing most of the world's infections. The Indian and Papua New Guinean endemic sites are included because of their important contribution to the global burden of vivax malaria; PNG has a high prevalence of asymptomatic P. vivax infections resembling P. falciparum infection in sub-Saharan Africa, and India contributes to nearly 80% of malaria cases in Southeast Asia. In Latin America, 3 countries are selected, Guatemala, Colombia and Brazil. In Guatemala P vivax is responsible for almost all malaria cases, in Colombia and Brazil it co-exists in different proportions with falciparum. Pregnant women will be enrolled at each site during routine antenatal care visits (ANC) and followed-up at the health facility until delivery or end of pregnancy. P. vivax malaria parasitaemia will be assessed at enrolment, at every contact with the health facility and at delivery. In a sub-sample of women, peripheral blood will be taken for immunological/molecular studies, and placental samples will be collected. To assess with precision the prevalence of infection (estimated to be around 4% on average) and to obtain sufficient number of pregnant women with P vivax infection to determine the impact on birthweight, 2000 pregnant women per site will be enrolled. Due to the likely low prevalence of infection in pregnancy, the number of pregnant women with P. vivax per site will probably not be enough to assess specific impact for each site, thus a multicentric study design will be used. Immunological analysis will be performed to unveil whether there are pregnancy-specific immune responses. Phenotypic and genotypic analyses of parasites from the placenta should reveal their adhesive properties and whether the accumulation of infected erythrocytes unique parasite population.'