HA-NFKB-VILI

Hypercapnic Acidosis and NF-kB in Ventilator Induced Lung Injury: Developing strategies to minimize lung injury and facilitate repair

 Coordinatore NATIONAL UNIVERSITY OF IRELAND, GALWAY 

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 Nazionalità Coordinatore Ireland [IE]
 Totale costo 1˙052˙556 €
 EC contributo 1˙052˙556 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2007-StG
 Funding Scheme ERC-SG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2013-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND, GALWAY

 Organization address address: University Road -
city: GALWAY

contact info
Titolo: Dr.
Nome: Jacinta
Cognome: Thornton
Email: send email
Telefono: 35391495684
Fax: 35391526388

IE (GALWAY) hostInstitution 0.00
2    NATIONAL UNIVERSITY OF IRELAND, GALWAY

 Organization address address: University Road -
city: GALWAY

contact info
Titolo: Prof.
Nome: John
Cognome: Laffey
Email: send email
Telefono: 353-91-544608
Fax: 353-91-545662

IE (GALWAY) hostInstitution 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

injury    ali    epithelial    nf    ards    biologic    acute    vili    beneficial    protective    induced    hypercapnia    lung    therapeutic    agent    deleterious    central    models    minimize    pulmonary    therapy    kb    diverse    repair    modulation    pathways    pathway    gene   

 Obiettivo del progetto (Objective)

'Acute Respiratory Distress Syndrome and Acute Lung Injury [ALI/ARDS] are devastating diseases, causing over 20,000 deaths annually in the US. Mechanical ventilation may worsen ALI/ARDS, a process termed Ventilator Induced Lung Injury [VILI]. Hypercapnic acidosis (HA) is a central component of lung ventilatory strategies to minimize VILI, and is a potent biologic agent, exerting a myriad of effects on diverse biologic pathways. Deliberately induced HA is protective in multiple lung injury models. However, HA may inhibit the host response to bacterial sepsis. Furthermore, HA may retard the repair process and slow recovery following ALI/ARDS. Hence, the diverse biologic actions of HA may result in net beneficial – or deleterious – effects depending on the specific context. An alternative approach is to manipulate a single key effector pathway, central to the protective effects of HA, which would also be effective in patients in whom hypercapnia is contra-indicated. Hypercapnia attenuates NF-kB activation, and may exert its effects – both beneficial and deleterious – via this mechanism. NF-kB is a pivotal regulator of the pro-inflammatory response, but is also a key epithelial cytoprotectant. Selective modulation of the NF-kB pathway, at the pulmonary epithelial surface, may accentuate the beneficial effects of HA on injury but minimize the potential for delayed tissue repair. We will investigate the contribution of NF-kB to the effects of HA, and characterize the direct effects modulation of NF-kB, in both in vitro and preclinical models of lung injury and repair. We will utilize pulmonary gene therapy, which facilitates delivery of high quantities of the therapeutic agent directly to the injury site, to maximize the potential for therapeutic benefit. These studies will provide novel insights into: key pathways contributing to lung injury and to repair; the role of HA and NF-kB in these processes; and the potential of pulmonary gene therapy in ALI/ARDS.'

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