#	Pagina
attuale pagina	/open-fp7/projects/92715/index.html

REBORNE

Regenerating Bone defects using New biomedical Engineering approaches

Coordinatore	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Marianne Cognome: Desmedt Email: send email Telefono: +33 2 40 35 06 69 Fax: +33 2 40 17 77 01
Nazionalità Coordinatore	France [FR]
Totale costo	15˙472˙075 €
EC contributo	11˙935˙340 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2009-single-stage
Funding Scheme	CP-IP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01 - 2015-06-30

Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Organization address address: 101 Rue de Tolbiac city: PARIS postcode: 75654 contact info Titolo: Ms. Nome: Marianne Cognome: Desmedt Email: send email Telefono: +33 2 40 35 06 69 Fax: +33 2 40 17 77 01	FR (PARIS)	coordinator	2˙121˙051.00
2	ETABLISSEMENT FRANCAIS DU SANG Organization address address: AVENUE DU STADE DE FRANCE 20 city: LA PLAINE SAINT DENIS CEDEX postcode: 93218 contact info Titolo: Mr. Nome: Laurent Cognome: Beauverger Email: send email Telefono: +33 2 47 36 21 60 Fax: +33 2 47362187	FR (LA PLAINE SAINT DENIS CEDEX)	participant	1˙439˙351.40
3	UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 contact info Nome: Frank Cognome: Gleixner Email: send email Telefono: +49 731 500 66397 Fax: +49 731 500 66392	DE (ULM)	participant	1˙356˙006.40
4	UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA Organization address address: VIA UNIVERSITA 4 city: MODENA postcode: 41100 contact info Titolo: Prof. Nome: Guiseppe Cognome: Torelli Email: send email Telefono: 39594224462 Fax: 39594223341	IT (MODENA)	participant	803˙109.25
5	UNIVERSIDAD AUTONOMA DE MADRID Organization address address: CALLE EINSTEIN, CIUDAD UNIV CANTOBLANCO RECTORADO 3 city: MADRID postcode: 28049 contact info Titolo: Ms. Nome: Ana Cognome: Amigo Email: send email Telefono: +34 914972897 Fax: +34 914972978	ES (MADRID)	participant	630˙499.50
6	FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO Organization address address: VIA FRANCESCO SFORZA 28 city: MILANO postcode: 20122 contact info Titolo: Dr. Nome: Rosaria Cognome: Giordano Email: send email Telefono: +39 255034053 Fax: +39 25458129	IT (MILANO)	participant	546˙715.56
7	UNIVERSITA DEGLI STUDI DI VERONA Organization address address: VIA DELL ARTIGLIERE 8 city: VERONA postcode: 37129 contact info Titolo: Dr. Nome: Giovanni Cognome: Menegatti Email: send email Telefono: 390458000000 Fax: 390458000000	IT (VERONA)	participant	481˙199.62
8	BIOMATLANTE SAS Organization address address: rue Edouard Belin - ZA des IV Nations 5 city: VIGNEUX DE BRETAGNE postcode: 44360 contact info Titolo: Ms. Nome: Isabelle Cognome: Bocherel Email: send email Telefono: +33 2 28020009 Fax: +33 2 28020010	FR (VIGNEUX DE BRETAGNE)	participant	477˙500.00
9	EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Dr. Nome: Ingo Cognome: Müller Email: send email Telefono: 4970710000000 Fax: 497071000000	DE (TUEBINGEN)	participant	465˙696.00
10	UNIVERSITETET I BERGEN Organization address address: Museplassen 1 city: BERGEN postcode: 5007 contact info Titolo: Ms. Nome: Inger Cognome: Gjesdahl Email: send email Telefono: 4755584980 Fax: 4755584991	NO (BERGEN)	participant	409˙868.75
11	XPAND BIOTECHNOLOGY BV Organization address address: PROFESSOR BRONKHORSTLAAN 10D city: BILTHOVEN postcode: 3723 MB contact info Titolo: Dr. Nome: Florence Cognome: De Groot Email: send email Telefono: +31 30 229 7294 Fax: +31 30 227299	NL (BILTHOVEN)	participant	401˙600.00
12	ALCIMED Organization address address: BOULEVARD DE MONTMORENCY 57 city: PARIS postcode: 75016 contact info Titolo: Mr. Nome: David Cognome: Bariau Email: send email Telefono: 33144304438 Fax: 33144304432	FR (PARIS)	participant	374˙964.00
13	ISTITUTO ORTOPEDICO RIZZOLI Organization address address: VIA DI BARBIANO 1/10 city: BOLOGNA postcode: 40136 contact info Titolo: Dr. Nome: Andrea Cognome: Rizzi Email: send email Telefono: 390516000000 Fax: 390516000000	IT (BOLOGNA)	participant	363˙180.00
14	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mr. Nome: Udo Cognome: Schreiner Email: send email Telefono: 496131000000 Fax: 496131000000	DE (MUENCHEN)	participant	352˙448.88
15	UNIVERSITAT POLITECNICA DE CATALUNYA Organization address address: Jordi Girona 31 city: BARCELONA postcode: 8034 contact info Titolo: Prof. Nome: Maria Pau Cognome: Ginebra Email: send email Telefono: +34 934017706 Fax: +34 934016706	ES (BARCELONA)	participant	304˙855.00
16	KITOZYME SA Organization address address: RUE HAUTE CLAIRE PARC INDUSTRIEL 4 city: HERSTAL postcode: 4040 contact info Titolo: Mr. Nome: Arnaud Cognome: Hamers Email: send email Telefono: +32 4 2598500 Fax: +32 4 2598509	BE (HERSTAL)	participant	300˙160.00
17	UNIVERSITATEA DE MEDICINA SI FARMACE VICTOR BABES TIMISOARA Organization address address: PIATA EFTIMIE MURGU 2A city: TIMISOARA postcode: 300041 contact info Nome: Constanta Cognome: Caplar Email: send email Telefono: 40256201290 Fax: 40256220479	RO (TIMISOARA)	participant	247˙600.00
18	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 contact info Titolo: Dr. Nome: Nathalie Cognome: Rouas-Freiss Email: send email Telefono: +33 1 57276801 Fax: +33 1 48031960	FR (PARIS 15)	participant	224˙994.00
19	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX contact info Titolo: Dr. Nome: P.J.A. Cognome: De Koning Email: send email Telefono: 31887559883 Fax: 31887555504	NL (UTRECHT)	participant	199˙940.00
20	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS Organization address address: 3 Avenue Victoria city: PARIS postcode: 75004 contact info Titolo: Mr. Nome: Christophe Cognome: Misse Email: send email Telefono: +33 1 44841770 Fax: +33 1 44841788	FR (PARIS)	participant	121˙388.00
21	HOPITAL UNIVERSTAIRE DE TOURS Organization address city: TOURS CEDEX 1 postcode: 37044 contact info Titolo: Prof. Nome: Philippe Cognome: Rosset Email: send email Telefono: +33 247475915 Fax: +33 2 47475912	FR (TOURS CEDEX 1)	participant	112˙050.00
22	CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES Organization address address: Allee de l'Ile Gloriette 5 city: NANTES postcode: 44093 contact info Titolo: Ms. Nome: Annes Cognome: Brethet Email: send email Telefono: +33 2 53 48 28 25 Fax: +33 2 53 48 28 26	FR (NANTES)	participant	99˙892.17
23	AZIENDA OSPEDALIERO-UNIVERSITARIA ANNA MEYER Organization address address: VIALE PIERACCINI 24 city: FIRENZE postcode: 50139 contact info Titolo: Dr. Nome: Franco Cognome: Bambi Email: send email Telefono: +39 055 5662991	IT (FIRENZE)	participant	88˙800.00
24	UNIVERSITE DE LIEGE Organization address city: LIEGE postcode: 4000 contact info Titolo: Prof. Nome: Eric Cognome: Rompen Email: send email Telefono: +32 4 366 82 90 Fax: +32 4 366 82 90	BE (LIEGE)	participant	12˙470.40

Mappa

Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

orthopaedic surgery mesenchymal trials patients stem tissue maxillofacial grafts bone biomaterials allogenic cells sources autologous clinical children reborne

Obiettivo del progetto (Objective)

'Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autografts account for more than 80% of total graft volume. Significant growth opportunities exist for synthetic bone grafts in association with mesenchymal stem cells from autologous or allogenic sources as alternatives to biological bone grafts in orthopaedic and maxillofacial surgery. The objectives of REBORNE is to perform clinical trials using advanced biomaterials and cells triggering bone healing in patients. In order to reach this goal, five phase II clinical studies with 20 patients are proposed in 12 clinical centres spread in 8 European countries. Three orthopaedic trials concerning the treatment of long bone fractures and osteonecrosis of the femoral head in adults or children will be conducted using bioceramics, hydrogel for percuteneous injection and stem cells from autologous or allogenic sources. Clinical research will also concern maxillofacial surgery with bone augmentation prior to dental implants and the reconstruction of cleft palates in children. The safety and efficacy of the new therapies will be assessed clinically using X-rays, CT scans and MRI as well as histology of biopsies. These ambitious clinical targets will require research and development efforts from a large consortium of top world class laboratories, SMEs manufacturing biomaterials, GMP-cell producing facilities and surgeons in hospitals as well as the consideration of ethical and regulatory issues. It is expected that REBORNE will expand the competitiveness of Europe through the patenting of new CE-marked bioproducts in the field of regenerative medicine.'

Introduzione (Teaser)

Bone tissue engineering is a novel approach that has received much attention lately as a promising alternative to autologous bone transplantation. An EU-funded study proposed the utilisation of mesenchymal stem cells (MSCs) for bone regeneration.