TIMET

Linking the clock to metabolism

Coordinatore	THE UNIVERSITY OF EDINBURGH    more  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 650 9023
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	7˙652˙635 €
EC contributo	5˙844˙329 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2009-3
Funding Scheme	CP-IP
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-03-01   -   2015-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 650 9023	UK (EDINBURGH)	coordinator	1˙039˙394.00
2	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Dr. Nome: Wilhelm Cognome: Gruissem Email: send email Telefono: +41 44 632 0857 Fax: +41 44 632 1079	CH (ZUERICH)	participant	1˙639˙208.00
3	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Mr. Nome: Lothar Cognome: Grube Email: send email Telefono: +49 331 567 8400 Fax: +49 331 567 8408	DE (MUENCHEN)	participant	1˙459˙000.00
4	JOHN INNES CENTRE  Organization address address: "Norwich Research Park, Colney" city: NORWICH postcode: NR4 7UH contact info Titolo: Dr. Nome: Mary Cognome: Anderson Email: send email Telefono: +44 1603 450244 Fax: +44 1603 450045	UK (NORWICH)	participant	599˙000.00
5	Nome Ente NON disponibile  Organization address address: Jordi Girona 18 city: BARCELONA postcode: 8034 contact info Titolo: Ms. Nome: Lali Cognome: Sanz Email: send email Telefono: +34 934 006 146 Fax: +34 932 045 904	ES (BARCELONA)	participant	508˙250.00
6	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN  Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX contact info Titolo: Dr. Nome: Elizabeth Cognome: Rattray Email: send email Telefono: +44 1224 274369 Fax: +44 1224 272319	UK (ABERDEEN)	participant	303˙647.00
7	UNIVERSITY OF GLASGOW  Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Mr. Nome: Joe Cognome: Galloway Email: send email Telefono: +44 141 330 3884	UK (GLASGOW)	participant	287˙512.20
8	THE SCOTTISH CROP RESEARCH INSTITUTE  Organization address address: "ERROL ROAD, INVERGOWRIE" city: DUNDEE postcode: DD2 5DA contact info Titolo: Dr. Nome: Neil Cognome: Hattersley Email: send email Telefono: +44 1382 562 731 Fax: +44 1382 568 503	UK (DUNDEE)	participant	4˙739.98
9	THE JAMES HUTTON INSTITUTE  Organization address address: ERROL ROAD INVERGOWRIE city: DUNDEE postcode: DD2 5DA contact info Titolo: Mrs. Nome: Karen Cognome: Robb Email: send email Telefono: +44 1382 56 8769 Fax: +44 844 928 5429	UK (DUNDEE)	participant	3˙577.82

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Optimal plant growth requires the orchestration of carbon metabolism over the day-night cycle, to avoid periods of starvation at night. Metabolism and growth at night are fueled by carbohydrates released by degradation of starch, synthesised from photosynthesis in the preceding day. Starch synthesis and degradation are regulated such that starch reserves are almost but not quite exhausted at the end of the night, in both long and short nights. We have recently found that this robust regulation is a function of the circadian clock, an endogenous timer that allows plants to anticipate and prepare for daily changes in their environment, and a paradigm for Systems Biology. The clock controls the rate of starch degradation at night, so that reserves last until the anticipated dawn. Starvation and growth arrest are avoided. This important discovery opens the way to new levels of understanding of the control of plant growth and productivity. TiMet assembles world leaders in experimental and theoretical plant Systems Biology to understand the regulatory interactions between the clock gene circuit and metabolism, and their emergent effects on growth and productivity. In addition to starch metabolism, we will study isoprenoid synthesis, an essential metabolic process linking starch metabolism to growth and development. Jointly-conducted experiments will use responses to day-length and light-quality regimes that perturb clock function, and a large set of mutants deficient in clock or central metabolic functions. High throughput technologies will enable study of transcriptional, post-transcriptional, translational and post-translational events, providing a depth of analysis hitherto unattained for either the clock or metabolism in plants. Innovative data mining and modelling platforms will underpin new, mechanistic models of each subsystem, will integrate them for the first time, and test the emergent effects of this dynamic system on plant growth rate and productivity.'

Introduzione (Teaser)

Researchers have collated a wide array of data on plant metabolism and the biological rhythms that govern this process. Using this data, they have built new and updated models of gene expression in plants.