GAMBA
Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis
| Coordinatore | KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Organization address
address: ISMANINGER STRASSE 22 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.gamba-project.eu/ |
| Totale costo | 4˙080˙393 € |
| EC contributo | 3˙198˙849 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2009-SMALL-3 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-09-01 - 2013-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Organization address
address: ISMANINGER STRASSE 22 contact info |
DE (MUENCHEN) | coordinator | 619˙792.00 |
| 2 |
AO-FORSCHUNGSINSTITUT DAVOS
Organization address
address: Clavadelerstrasse 8 contact info |
CH (Davos Platz) | participant | 457˙798.00 |
| 3 |
NATIONAL UNIVERSITY OF IRELAND, GALWAY
Organization address
address: University Road - contact info |
IE (GALWAY) | participant | 381˙999.00 |
| 4 |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address
address: 's Gravendijkwal 230 contact info |
NL (ROTTERDAM) | participant | 354˙200.00 |
| 5 |
BIOMATLANTE SAS
Organization address
address: rue Edouard Belin - ZA des IV Nations 5 contact info |
FR (VIGNEUX DE BRETAGNE) | participant | 349˙560.00 |
| 6 |
OZ BIOSCIENCES SAS
Organization address
address: Parc scientifique et Technologique de Luminy - BAT CCIMP contact info |
FR (MARSEILLE) | participant | 330˙800.00 |
| 7 |
IRCCS AZIENDA OSPEDALIERA UNIVERSITARIA SAN MARTINO-IST-ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO
Organization address
address: LARGO ROSANNA BENZI 10 contact info |
IT (GENOVA) | participant | 269˙600.00 |
| 8 |
Nome Ente NON disponibile
Organization address
city: Weilheim contact info |
DE (Weilheim) | participant | 244˙600.00 |
| 9 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 190˙500.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'This consortium develops a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The S&T objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this project. The GAMBA platform is going to implement a concept of spatiotemporal control of regenerative bioactivity on command and demand. A gene-activated matrix is a biomaterial with embedded gene vectors that will genetically modify cells embedded in the matrix. The platform comprises modules that self-adapt to the biological environment and that can be independently addressed with endogenous biological and exogenous physical or pharmacological stimuli, resulting in a temporally and spatially coordinated growth factor gene expression pattern. This reproduces, within the matrix, key elements of natural tissue formation. The modules are a biomimetic hyaluronan gel, a ceramic matrix, growth factor-encoding gene vector nanoparticles, magnetic nanoparticles and mesenchymal stem cells. Anatomical adaptivity is achieved with engineered thermal properties of the polymer matrix, which embeds other modules, selected according to functional requirements. Mechanical support is provided by Micro Macroporous Biphasic Calcium Phosphate (MBCP™), a resorbable material approved for clinical use. Spatiotemporal control of bioactivity and responsiveness to physiological conditions is represented, firstly, in the spatial distribution and release profiles of gene vectors within the composite matrix and, secondly, by letting local and external biological or physical stimuli activate the promoters driving the expression of vector-encoded transgenes. This innovative concept is implemented by a multidisciplinary team from leading European institutions combining scientific excellence with a focused plan of dissemination, public participation, gender equality and transition to market.'
Introduzione (Teaser)
Exploiting the natural processes of tissue regeneration and repair could constitute a promising approach for reversing many degenerative disorders. However, reproducing exactly what happens in nature requires tight spatial and temporal control.