NEMATODESYSTEMHEALTH

A Systems Biology Approach to controlling Nematode Infections of Livestock

Coordinatore	UNIVERSITY OF GLASGOW    more  Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Prof. Nome: Michael James Cognome: Stear Email: send email Telefono: +44 141 300 5762 Fax: +44 141 330 2483
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	3˙365˙535 €
EC contributo	3˙365˙535 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-ITN
Funding Scheme	MC-ITN
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-01-01   -   2014-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW  Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Prof. Nome: Michael James Cognome: Stear Email: send email Telefono: +44 141 300 5762 Fax: +44 141 330 2483	UK (GLASGOW)	coordinator	736˙605.00
2	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Dr. Nome: Jacques Cognome: Cabaret Email: send email Telefono: +33 2 47427768 Fax: +33 2 47427774	FR (PARIS CEDEX 07)	participant	502˙566.00
3	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Prof. Nome: Torres Cognome: Sweeney Email: send email Telefono: +353 1 7166244 Fax: +353 1 7161216	IE (DUBLIN)	participant	496˙512.00
4	WAGENINGEN UNIVERSITY  Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Ms. Nome: Gerda Cognome: Bakker Email: send email Telefono: +31 317 483382 Fax: +31 317 483952	NL (WAGENINGEN)	participant	473˙988.00
5	UNIVERSIDAD DE LEON  Organization address address: "Avenida de la Facultad, 25" city: LEON postcode: 24071 contact info Titolo: Ms. Nome: Carmen Cognome: Martinez-Rey Email: send email Telefono: +34 987 291667 Fax: +34 987 291668	ES (LEON)	participant	448˙492.00
6	BAYERISCHE LANDESANSTALT FUR LANDWIRTSCHAFT  Organization address address: VOTTINGER STRASSE 38 city: FREISING postcode: 85354 contact info Titolo: Dr. Nome: Johannes Cognome: Buitkamp Email: send email Telefono: +49 89 99141130 Fax: +49 89 99141199	DE (FREISING)	participant	444˙030.00
7	TOPIGS RESEARCH CENTER IPG BV  Organization address address: Schoenaker 6 city: BEUNINGEN GLD postcode: 6641SZ contact info Titolo: Dr. Nome: Jan Cognome: Merks Email: send email Telefono: +31 24 6779999 Fax: +31 24 6779800	NL (BEUNINGEN GLD)	participant	206˙012.00
8	ReactivLab Ltd  Organization address address: "The Square, University Avenue 13" city: Glasgow postcode: G12 8QQ contact info Titolo: Prof. Nome: Peter David Cognome: Eckersall Email: send email Telefono: +44 141 330 5732 Fax: +44 141 330 2483	UK (Glasgow)	participant	57˙330.00
9	Agris Sardegna - Agenzia per la Ricerca in Agricoltura  Organization address address: "Loc. Bonassai SS 291 Km 18,6" city: Sassari postcode: 7100 contact info Titolo: Dr. Nome: Antonello Cognome: Carta Email: send email Telefono: +39 079 781612 Fax: +39 079 2831545	IT (Sassari)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'Nematodes are among the most serious threats to livestock. They cause disease and death but they also compromise production. Even a mild infection can cause a relative protein deficiency and reduce weight gain by 25% . In the UK sheep industry alone, nematode infection costs over 100 million Euros a year . The mainstay of current control measures is anthelmintic treatment but this is threatened by the evolution of drug resistance in parasite populations. Alternative or supplementary control measures are urgently needed. The most promising option for control of nematodes is exploitation of genetic variation which is cheap, surprisingly rapid and has proved to be successful in Australia and New Zealand. There are two obstacles to exploiting genetic variation in resistance to nematodes. Many farmers lack expertise in breeding for disease resistance; simplified breeding strategies that utilise markers for disease resistance will help here. Also, there are concerns about sustainability of breeding for resistance to nematodes.

A systems biology approach is necessary in order to develop the comprehensive understanding necessary to simplify breeding to ensure that disease control is likely to be sustainable. A systems approach will also help to identify the most suitable combination of approaches under different circumstances. Systems biology combines a variety of disciplines in a quantitative way to achieve a coherent, consistent and comprehensive understanding of host-parasite relationships.

This project aims to identify markers for host resistance to nematodes and to enhance our understanding of the host-parasite interaction. We will train a cadre of researchers with the necessary skills to apply quantitative approaches to parasitology and with the essential experience to apply this knowledge to the livestock sector.'

Introduzione (Teaser)

Nematode infections cost the European sheep industry alone over EUR 100 million annually. A systems biology approach can encourage the livestock sector to harness genetic know-how to control nematodes.