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Muscle stress relief SIGNED

Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Muscle stress relief project word cloud

Explore the words cloud of the Muscle stress relief project. It provides you a very rough idea of what is the project "Muscle stress relief" about.

interdisciplinary expertise innovation vice thereby teams strategies functionally predicted impairing animal joint countries medical sme humoral inactive ageing myofibril africa mechanisms monitoring versa scheme academic disease incidence translational innovative clinical translation capacities stages lung collaborative edge risk weakness diverse contractility organ liver complementary detection force heart interventions cross models seconded cutting variety multidisciplinary regulation lifestyles stage myopathy myofilament south socioeconomic organs team inter proteins secondary preventive smes muscle stress nutrition underlying groups six kidney therapeutic endemic nine regenerative university metabolism causing lifestyle talk myopathies progressive chronic network ultimately participate unbalanced

Project "Muscle stress relief" data sheet

The following table provides information about the project.

Coordinator	PANEPISTIMIO THESSALIAS Organization address address: ARGONAFTON FILELLINON city: VOLOS postcode: 38221 website: www.uth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://www.musclestressrelief.eu
Total cost	1˙606˙500 €
EC max contribution	1˙458˙000 € (91%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PANEPISTIMIO THESSALIAS PANEPISTIMIO THESSALIAS Organization address address: ARGONAFTON FILELLINON city: VOLOS postcode: 38221 website: www.uth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (VOLOS)	coordinator	144˙000.00
2	UNIVERSITY OF ST MARK & ST JOHN UNIVERSITY OF ST MARK & ST JOHN Organization address address: DERRIFORD ROAD city: PLYMOUTH postcode: PL6 8BH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (PLYMOUTH)	participant	189˙000.00
3	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	180˙000.00
4	TZARTOS - DIAGNOSIS & RESEARCH IN NEUROIMMUNOLOGY MEDICAL LIMITED LIABILITY COMPANY TZARTOS - DIAGNOSIS & RESEARCH IN NEUROIMMUNOLOGY MEDICAL LIMITED LIABILITY COMPANY Organization address address: Eslin 3 city: Athens postcode: 115 23 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (Athens)	participant	166˙500.00
5	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 website: www.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	139˙500.00
6	ASSOCIATION GENETHON ASSOCIATION GENETHON Organization address address: RUE DE L INTERNATIONALE 1 BIS city: EVRY postcode: 91002 website: www.genethon.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (EVRY)	participant	130˙500.00
7	MYOMEDIX GMBH MYOMEDIX GMBH Organization address address: IM BIENGARTEN 36 city: NECKARGEMUEND postcode: 69151 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NECKARGEMUEND)	participant	126˙000.00
8	CHRISTOS PAPADOPOULOS & SIA OE CHRISTOS PAPADOPOULOS & SIA OE Organization address address: KITROUS EPISKOPOU 71 city: KARDITSA postcode: 431 00 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (KARDITSA)	participant	117˙000.00
9	FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS Organization address address: Via Orus Giuseppe 2 city: PADOVA postcode: 35129 website: www.vimm.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	participant	94˙500.00
10	UNIVERSITAT KONSTANZ UNIVERSITAT KONSTANZ Organization address address: UNIVERSITATSSTRASSE 10 city: KONSTANZ postcode: 78464 website: www.uni-konstanz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KONSTANZ)	participant	90˙000.00
11	KNIGHT SCIENTIFIC LIMITED KNIGHT SCIENTIFIC LIMITED Organization address address: 18 WESTERN COLLEGE ROAD city: PLYMOUTH DEVON postcode: PL4 7AG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (PLYMOUTH DEVON)	participant	40˙500.00
12	DLD GESELLSCHAFT FUR DIAGNOSTIKA UND MEDIZINISCHE GERATE MBH DLD GESELLSCHAFT FUR DIAGNOSTIKA UND MEDIZINISCHE GERATE MBH Organization address address: ADLERHORST 15 city: HAMBURG postcode: 22459 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	31˙500.00
13	ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT Organization address address: Square J 5 city: MANNHEIM postcode: 68159 website: www.zi-mannheim.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MANNHEIM)	participant	9˙000.00
14	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	0.00
15	IMMUNDIAGNOSTIK AG IMMUNDIAGNOSTIK AG Organization address address: STUBENWALD ALLEE 8 A city: BENSHEIM postcode: 64625 website: www.immundiagnostik.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BENSHEIM)	participant	0.00
16	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	0.00
17	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	0.00
18	STELLENBOSCH UNIVERSITY STELLENBOSCH UNIVERSITY Organization address address: VICTORIA STREET ADMINISTRATION B BUILDING city: STELLENBOSCH postcode: 7600 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ZA (STELLENBOSCH)	partner	0.00
19	University of Arizona College of Medicine-Phoenix University of Arizona College of Medicine-Phoenix Organization address address: 3420 Mercy Road, Ste 312 city: Gilbert postcode: 85297 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Gilbert)	partner	0.00
20	University of California San Francisco School of Medicine University of California San Francisco School of Medicine Organization address address: Parnassus Avenue 521 city: San Francisco postcode: 94143-0410 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (San Francisco)	partner	0.00
21	UNIVERSITY OF FLORIDA UNIVERSITY OF FLORIDA Organization address address: GRINTER HALL 223 city: GAINESVILLE postcode: 32611 5500 website: http://www.ufl.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (GAINESVILLE)	partner	0.00

Map

Project objective

A diverse variety of medical or lifestyle conditions lead to a progressive loss of muscle force by functionally impairing myofibril contractility and causing ultimately myofibril loss. Major underlying risk factors of chronic muscle force loss are ageing, inactive lifestyles, and unbalanced nutrition. Together, these factors are predicted to lead to an endemic incidence of muscle weakness both in the developed countries. Clinical research on the mechanisms involved requires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung. To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with three leading teams in the U.S. with expertise in myopathy animal models, myofilament proteins and translation of muscle research into therapeutic interventions, and with one team from South Africa with cutting-edge expertise in the regulation of regenerative capacities in muscle. Importantly, five SMEs will participate in this RISE network that provide expertise in early muscle disease detection, monitoring, and the developing preventive strategies: Their knowledge on muscle disease detection at early stages and their monitoring during interventions will promote translational innovation. To implement innovation and our joint research program, both early stage and advanced researchers will be seconded from the academic nine teams to these five SMEs and vice versa. Thereby, this RISE scheme will establish a long-term collaborative University-SME driven translational innovative research program innovation in our interdisciplinary field of growing socioeconomic medical importance.

Deliverables

List of deliverables.
Management	Websites, patent fillings, videos etc.	2020-01-28 10:54:17
Workshop	Other	2020-01-28 10:54:17

Take a look to the deliverables list in detail: detailed list of Muscle stress relief deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Giulia Favaro, Vanina Romanello, Tatiana Varanita, Maria Andrea Desbats, Valeria Morbidoni, Caterina Tezze, Mattia Albiero, Marta Canato, Gaia Gherardi, Diego De Stefani, Cristina Mammucari, Bert Blaauw, Simona Boncompagni, Feliciano Protasi, Carlo Reggiani, Luca Scorrano, Leonardo Salviati, Marco Sandri DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10226-9	Nature Communications 10/1	2020-03-05
2019	Vanina Romanello, Marco Scalabrin, Mattia Albiero, Bert Blaauw, Luca Scorrano, Marco Sandri Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles published pages: 597, ISSN: 2073-4409, DOI: 10.3390/cells8060597	Cells 8/6	2020-03-05
2020	John S. Tzartos, Katerina Karagiorgou, Dimitrios Tzanetakos, Marianthi Breza, Maria Eleftheria Evangelopoulos, Sygkliti-Henrietta Pelidou, Christos Bakirtzis, Ioannis Nikolaidis, Georgios Koutsis, Konstantinos Notas, Elisabeth Chroni, Ioannis Markakis, Nikolaos C. Grigoriadis, Maria Anagnostouli, Anastasios Orologas, Dimitrios Parisis, Theodoros Karapanayiotides, Dimitra Papadimitriou, Vasiliki Ko Deciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays published pages: 116673, ISSN: 0022-510X, DOI: 10.1016/j.jns.2020.116673	Journal of the Neurological Sciences 410	2020-02-20
2019	J.G. Silvestre, I.L. Baptista, W.J. Silva, A. Cruz, M.T. Silva, E.H. Miyabara, S. Labeit, A.S. Moriscot The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts published pages: , ISSN: 0100-879X, DOI: 10.1590/1414-431x20198551	Brazilian Journal of Medical and Biological Research 52/9	2020-02-13
2019	Robbert J. van der Pijl, Henk L. Granzier, Coen A. C. Ottenheijm Diaphragm contractile weakness due to reduced mechanical loading: role of titin published pages: C167-C176, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00509.2018	American Journal of Physiology-Cell Physiology 317/2	2020-01-28
2019	William JosÃ© Silva, Flavia Aparecida GraÃ§a, AndrÃ© Cruz, JoÃ£o Guilherme Silvestre, Siegfried Labeit, Elen Haruka Miyabara, Chao Yun Irene Yan, Da Zhi Wang, Anselmo Sigari Moriscot miRâ€29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophyâ€related genes published pages: e13278, ISSN: 1748-1708, DOI: 10.1111/apha.13278	Acta Physiologica	2020-01-28
2019	Anselmo Sigari Moriscot, Igor Luchini Baptista, William JosÃ© Silva, JoÃ£o Guilherme Silvestre, Volker Adams, Alexander Gasch, Julius Bogomolovas, Siegfried Labeit MuRF1 and MuRF2 are key players in skeletal muscle regeneration involving myogenic deficit and deregulation of the chromatin-remodeling complex published pages: 1-25, ISSN: 2617-1619, DOI: 10.1002/j.2617-1619.2019.tb00010.x	JCSM Rapid Communications 2/1	2020-01-28
2018	Nikolaos Trakas, Socrates J. Tzartos Immunostick ELISA for rapid and easy diagnosis of myasthenia gravis published pages: 107-112, ISSN: 0022-1759, DOI: 10.1016/j.jim.2018.06.016	Journal of Immunological Methods 460	2020-01-28
2017	Mitrou GI, Poulianiti KP, Koutedakis Y, Jamurtas AZ, Maridaki MD, Stefanidis I, Sakkas GK, Karatzaferi C Functional responses of uremic single skeletal muscle fibers to redox imbalances published pages: 3-7, ISSN: 1108-4189, DOI:	Hippokratia 21(1)	2020-01-28
2018	Johan Lindqvist, Marloes van den Berg, Robbert van der Pijl, Pleuni E. Hooijman, Albertus Beishuizen, Judith Elshof, Monique de Waard, Armand Girbes, Angelique Spoelstra-de Man, Zhong-Hua Shi, Charissa van den Brom, Sylvia Bogaards, Shengyi Shen, Joshua Strom, Henk Granzier, Jeroen Kole, RenÃ© J. P. Musters, Marinus A. Paul, Leo M. A. Heunks, Coen A. C. Ottenheijm Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers published pages: 472-485, ISSN: 1073-449X, DOI: 10.1164/rccm.201709-1917OC	American Journal of Respiratory and Critical Care Medicine 198/4	2020-01-28
2017	Caterina Tezze, Vanina Romanello, Maria Andrea Desbats, Gian Paolo Fadini, Mattia Albiero, Giulia Favaro, Stefano Ciciliot, Maria Eugenia Soriano, Valeria Morbidoni, Cristina Cerqua, Stefan Loefler, Helmut Kern, Claudio Franceschi, Stefano Salvioli, Maria Conte, Bert Blaauw, Sandra Zampieri, Leonardo Salviati, Luca Scorrano, Marco Sandri Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence published pages: 1374-1389.e6, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2017.04.021	Cell Metabolism 25/6	2020-01-28
2017	Christina Karatzaferi, Nancy Adamek, Michael A Geeves Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue published pages: ajpcell.00023.20, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00023.2017	American Journal of Physiology - Cell Physiology	2020-01-28
2015	C. J. Malavaki, G. K. Sakkas, G. I. Mitrou, A. Kalyva, I. Stefanidis, K. H. Myburgh, C. Karatzaferi Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy published pages: 405-421, ISSN: 0142-4319, DOI: 10.1007/s10974-015-9439-8	Journal of Muscle Research and Cell Motility 36/6	2020-01-28
2017	Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova, Siegfried Labeit The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-017-3811-6	BMC Genomics 18/1	2020-01-28
2016	Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, DovilÄ— KarÄiauskaitÄ—, Pranas Å erpytis, Virginija GrabauskienÄ—, Dittmar Labeit, Siegfried Labeit Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury published pages: 232-234, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2016.03.045	International Journal of Cardiology 212	2020-01-28
2016	C. Stergiou, K. Lazaridis, V. Zouvelou, J. Tzartos, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. Losen, P. Martinez-Martinez, K.A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, N.E. Gilhus, C. Casasnovas Pons, J. Pitha, M. JakubÃkova, F. Hanisch, J. Bogomolovas, D. Labeit, S. Labeit, S.J. Tzartos Titin antibodies in â€œseronegativeâ€ myasthenia gravis â€” A new role for an old antigen published pages: 108-115, ISSN: 0165-5728, DOI: 10.1016/j.jneuroim.2016.01.018	Journal of Neuroimmunology 292	2020-01-28
2017	Thomas Scott Bowen, Volker Adams, Sarah Werner, Tina Fischer, Paulien Vinke, Maria Noel Brogger, Norman Mangner, Axel Linke, Peter Sehr, Joe Lewis, Dittmar Labeit, Alexander Gasch, Siegfried Labeit Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia published pages: , ISSN: 2190-5991, DOI: 10.1002/jcsm.12233	Journal of Cachexia, Sarcopenia and Muscle	2020-01-28
2019	Konstantina P. Poulianiti, Aggeliki Karioti, Antonia Kaltsatou, Georgia I. Mitrou, Yiannis Koutedakis, Konstantinos Tepetes, Grigoris Christodoulidis, Giannis Giakas, Maria D. Maridaki, Ioannis Stefanidis, Athanasios Z. Jamurtas, Giorgos K. Sakkas, Christina Karatzaferi Evidence of Blood and Muscle Redox Status Imbalance in Experimentally Induced Renal Insufficiency in a Rabbit Model published pages: 1-14, ISSN: 1942-0900, DOI: 10.1155/2019/8219283	Oxidative Medicine and Cellular Longevity 2019	2020-01-28
2019	Georgia I. Mitrou, Giorgos K. Sakkas, Konstantina P. Poulianiti, Aggeliki Karioti, Konstantinos Tepetes, Grigorios Christodoulidis, Giannis Giakas, Ioannis Stefanidis, Michael A. Geeves, Yiannis Koutedakis, Christina Karatzaferi Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency published pages: 259-265, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2018.10.035	Journal of Biomechanics 82	2020-01-28

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