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DISSection SIGNED

Doctoral Industrial School on Human Skin models for Staphylococcal infections

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DISSection project word cloud

Explore the words cloud of the DISSection project. It provides you a very rough idea of what is the project "DISSection" about.

protective first students complemented organotypic valid scientific university unfortunately believe cutaneous skills bacterial good generate macrophages pathogen skin optimized correlates neutrophils equivalent degree never infection science applicative mass technologies virulence hindered training visits rarely models innovative spectrometry basic emergency staphylococcus aureus expresses dermatology vaccine scaffolds advantage human animal immune associate cells dimensional pluripotent competent edge area protection matrix opportunity vaccines integrate immunity communities novartis receive utrecht infections epithelial model stem renowned components grow mechanisms courses cutting alternative hydrogel complementary phd lack pathogenesis

Project "DISSection" data sheet

The following table provides information about the project.

Coordinator	GLAXOSMITHKLINE VACCINES SRL Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.dissection.eu
Total cost	1˙026˙871 €
EC max contribution	1˙026˙871 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-EID
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2020-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	GLAXOSMITHKLINE VACCINES SRL GLAXOSMITHKLINE VACCINES SRL Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	coordinator	516˙122.00
2	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	510˙748.00

Map

Project objective

Staphylococcus aureus (S. aureus) is a major human pathogen and cutaneous infections are among the leading cause of emergency department visits. Unfortunately, S. aureus vaccine development is hindered by the lack of known correlates of protection. Three dimensional organotypic human skin models may represent a valid alternative to animal infection model. Indeed, S. aureus expresses several human-specific virulence factors. However, at the present such models have been rarely used in the S. aureus research field and, to our knowledge, never with immune-competent models. Therefore, a major aim of this proposal is to develop a human skin equivalent and integrate key immune components in the epithelial matrix. To accomplish this goal we will take advantage of cutting-edge technologies, such as induced pluripotent stem cells to generate macrophages and neutrophils. The model will be used and optimized to the following main objectives: better understanding of human-specific pathogenesis of S. aureus as well as protective mechanisms against the pathogen; development of the first immune-competent human skin models for vaccine research; determine the role of bacterial communities on skin infections; provide alternative methods to animal models. The proposed scientific program will be complemented with a number of training courses based on specific skills for which both the University of Utrecht and Novartis Vaccines are renowned. Complementary courses on dermatology, human skin infections, hydrogel scaffolds, mass spectrometry, and induced pluripotent stem technology, will be held by associate partners. At the end of the project the students will receive a PhD degree in the area of Infection and Immunity. We believe that this project is at the leading edge of science and technology and represents a good opportunity for students that are willing to grow both in basic science as well as innovative and applicative research.

Deliverables

List of deliverables.
â€œSkin model & Vaccinologyâ€ workshops	Documents, reports	2019-05-09 11:48:55
Website	Websites, patent fillings, videos etc.	2019-05-09 11:48:56
Local Training reports	Documents, reports	2019-05-09 11:48:56
Annual DISSection meetings	Documents, reports	2019-05-09 11:48:56
Dissemination reports	Websites, patent fillings, videos etc.	2019-05-09 11:48:55
Meetings proceedings	Websites, patent fillings, videos etc.	2019-05-09 11:48:56
Transferable Skills Courses	Documents, reports	2019-05-09 11:48:55
Outreach reports	Documents, reports	2019-05-09 11:48:55
Recruitment	Other	2019-05-09 11:48:55
Supervisory Board	Other	2019-05-09 11:48:55

Take a look to the deliverables list in detail: detailed list of DISSection deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti, Fabio Bagnoli Human Organotypic Models for Anti-infective Research published pages: , ISSN: , DOI: 10.1007/82_2018_130	Current Topics in Microbiology and Immunology	2019-05-09

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The information about "DISSECTION" are provided by the European Opendata Portal: CORDIS opendata.