Explore the words cloud of the EVALVE project. It provides you a very rough idea of what is the project "EVALVE" about.
The following table provides information about the project.
Coordinator |
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://www.igbmc.fr/research/department/1/team/15/ |
Total cost | 2˙000˙000 € |
EC max contribution | 2˙000˙000 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-12-01 to 2021-11-30 |
Take a look of project's partnership.
# | ||||
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1 | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE | UK (LONDON) | coordinator | 798˙871.00 |
2 | CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE | FR (ILLKIRCH GRAFFENSTADEN) | participant | 1˙201˙128.00 |
Mechanical forces are fundamental to cardiovascular development and physiology. The interactions between mechanical forces and endothelial cells are mediated by mechanotransduction feedback loops. My lab is interested in understanding how hemodynamic forces modulate cardiovascular function and morphogenesis. Overall, our recent work is unraveling the biological links between mechanical forces, mechanotransduction and endothelial cell responses. The heart beats 2.6 billion times in a human lifetime and heart valves are amongst the most mechanically challenged structures of the body. The cardiac valves are made of endocardial cells (EdCs) and extracellular matrix components. Most valve diseases have their origins in embryogenesis, either as signs of abnormal developmental processes or the aberrant re-expression of fetal gene programs normally quiescent in adulthood.
This project is directed towards the elucidation of the biomechanical mechanism of mechanotransduction at the subcellular and molecular level and in addressing how EdCs integrate this information to form and maintain a functional cardiac valve. We will identify the mechanosensors at work in EdCs and their roles during cardiac valve development and repair. To do so, we will implement unique optical methodologies the lab has pioneered to characterize endocardial mechanotransduction: 1) Optical tweezing combined with mechanical stress reporters to test the mechanosensitivity of EdCs; 2) High resolution live microscopy and mathematical modeling to quantify mechanical forces; 3) 3D cell lineage studies to understand how cells respond and organize during pathological valve development. We will also use high-throughput mRNA- and ChIP-sequencing to characterize the transcriptional network activated by forces.
When completed this proposal will shed light on a critical, but little explored, aspect of congenital valve defects and will be useful for identifying new targets for therapeutic interventions.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Renee Wei-Yan Chow, Julien Vermot The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology published pages: 459, ISSN: 2046-1402, DOI: 10.12688/f1000research.10617.1 |
F1000Research 6 | 2020-01-29 |
2017 |
Renee Wei-Yan Chow, Julien Vermot The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology published pages: 459, ISSN: 2046-1402, DOI: 10.12688/f1000research.10617.1 |
F1000Research 6 | 2020-01-29 |
2018 |
Renee Wei-Yan Chow, Paola Lamperti, Emily Steed, Francesco Boselli, Julien Vermot Following Endocardial Tissue Movements via Cell Photoconversion in the Zebrafish Embryo published pages: , ISSN: 1940-087X, DOI: 10.3791/57290 |
Journal of Visualized Experiments 132 | 2020-01-29 |
2017 |
Lauren M. Goddard, Anne-Laure Duchemin, Harini Ramalingan, Bingruo Wu, Mei Chen, Sharika Bamezai, Jisheng Yang, Li Li, Michael P. Morley, Tao Wang, Marielle Scherrer-Crosbie, David B. Frank, Kurt A. Engleka, Stephen C. Jameson, Edward E. Morrisey, Thomas J. Carroll, Bin Zhou, Julien Vermot, Mark L. Kahn Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis published pages: 274-289.e5, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.09.023 |
Developmental Cell 43/3 | 2020-01-29 |
2019 |
Rita R. Ferreira, Hajime Fukui, Renee Chow, Andrej Vilfan, Julien Vermot The cilium as a force sensor−myth versus reality published pages: jcs213496, ISSN: 0021-9533, DOI: 10.1242/jcs.213496 |
Journal of Cell Science 132/14 | 2020-01-29 |
2018 |
Rita R. Ferreira, Guillaume Pakula, Lhéanna Klaeyle, Hajime Fukui, Andrej Vilfan, Willy Supatto, Julien Vermot Chiral Cilia Orientation in the Left-Right Organizer published pages: 2008-2016.e4, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.10.069 |
Cell Reports 25/8 | 2020-01-29 |
2018 |
Pedro Campinho, Paola Lamperti, Francesco Boselli, Julien Vermot Three-dimensional microscopy and image analysis methodology for mapping and quantification of nuclear positions in tissues with approximate cylindrical geometry published pages: 20170332, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0332 |
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1759 | 2020-01-29 |
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The information about "EVALVE" are provided by the European Opendata Portal: CORDIS opendata.
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