NANODNASEQUENCING

NanoTools for Ultra Fast DNA Sequencing

Coordinatore	INSTITUT ZA FIZIKU    more  Organization address address: Pregrevica 118 city: BEOGRAD postcode: 11080 contact info Titolo: Dr. Nome: Zikic Cognome: Radomir Email: send email Telefono: +381 11 3713185 Fax: +381 11 3162190
Nazionalità Coordinatore	Serbia [RS]
Sito del progetto	http://www.nanoDNAsequencing.org
Totale costo	2˙861˙368 €
EC contributo	2˙170˙925 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2007-SMALL-1
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-12-01   -   2011-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT ZA FIZIKU  Organization address address: Pregrevica 118 city: BEOGRAD postcode: 11080 contact info Titolo: Dr. Nome: Zikic Cognome: Radomir Email: send email Telefono: +381 11 3713185 Fax: +381 11 3162190	RS (BEOGRAD)	coordinator	0.00
2	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE  Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: László Cognome: Forró Email: send email Telefono: +41 21 693 4306 Fax: +41 21 693 4470	CH (LAUSANNE)	participant	0.00
3	Karlsruher Institut fuer Technologie  Organization address address: Kaiserstrasse 12 city: Karlsruhe postcode: 76131 contact info Titolo: Ms. Nome: Claudia Cognome: Sommer Email: send email Telefono: +49 721 608 42860	DE (Karlsruhe)	participant	0.00
4	NUWAVE SYSTEM LTD  Organization address address: PERCY STREET 5 OFFICE 4 city: LONDON postcode: W1T 1DG contact info Titolo: Mr. Nome: Cvitanovic Cognome: Nikola Email: send email Telefono: +44 20 21333904 Fax: +44 20 21333904	UK (LONDON)	participant	0.00
5	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Dr. Nome: Eran Cognome: Vardi Email: send email Telefono: 97226586676 Fax: 97226513205	IL (JERUSALEM)	participant	0.00
6	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: 35318961942 Fax: 35317071633	IE (DUBLIN)	participant	0.00
7	UNIVERSITAET REGENSBURG  Organization address address: UNIVERSITAETSSTRASSE 31 city: REGENSBURG postcode: 93053 contact info Titolo: Dr. Nome: Christian Cognome: Blomeyer Email: send email Telefono: +49 941 943 2309 Fax: +49 941 943 1545	DE (REGENSBURG)	participant	0.00

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 Obiettivo del progetto (Objective)

'The demand for a next-generation of technologies for DNA sequencing that will provide fast and affordable DNA decoding is pressing. Present bio-chemical schemes are time consuming and expensive, thus cheap and fast alternatives for DNA “reading” are of great need. This is now internationally recognized. For example, the US NIH recently awarded 40M$ in grants overpiloting projects to spur development of these innovative technologies. The goal of this project is to investigate a novel single-molecule DNA se-quencing nanotechnology protocol (gene sequencer) that has potential to sequence a molecule of genomic dimensions in hours without expensive and fault sensitive DNA copying steps and chemical reactions. The gene sequencer is based on the electrical characterization of individual nucleo-bases, while DNA passes through a nanopore with integrated nanotube side-electrodes. The research proposed here will provide a unique combina-tion of state of the art capabilities for cutting and usage of single wall carbon nanotubes as electrodes forming a lithographically fabricated “nanogap” with single-nanometer precision. In addition, the synergy of consortium resources for electrical characterization and leading theoretical skills for nanotransport will provide new solutions and information for an answer on the proof-of-principle question: is it possible to detect different types of DNA bases by their electrical properties? The overall objective of our collaborative research is to develop cheap and high-speed DNA sequencing technology. This will be achieved trough the following steps: 1. Fabrication of single wall carbon nanotube junction-gate for molecular recognition; 2. Exploring the interaction and conduction mechanisms between DNA and nanotube-electrode and DNA-nanopore; 3. Electrical characterization of the DNA nucleobases; 4. Development of model nano-electronic device for single-base DNA electrical characterization and decoding.'