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ActiTOX SIGNED

Active organotypic models for nanoparticle toxicological screening

Total Cost €

EC-Contrib. €

Partnership

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ActiTOX project word cloud

Explore the words cloud of the ActiTOX project. It provides you a very rough idea of what is the project "ActiTOX" about.

bioreactor innovation fulfils rate esr disadvantages creates attrition evaluation prior screening drug social stem platform animal oint pluripotent ethical relevance drugs academia excretion actions 3d absorption nanoparticles workshop toxicological gap functional ipscs biomimetic scaffolds human cells delivers mediate networking closing lasting adme undergoing clinical point view er delivering industry toxicity training metabolism customers goals content employ secondments protocols microfluidics reacts area stakeholders helps actitox economy modular cooperation network scalable vitro form efficient

Project "ActiTOX" data sheet

The following table provides information about the project.

Coordinator	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	1˙191˙400 €
EC max contribution	1˙191˙400 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2018
Funding Scheme	MSCA-RISE
Starting year	2019
Duration (year-month-day)	from 2019-08-01 to 2023-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	coordinator	161˙000.00
2	INOCURE SRO INOCURE SRO Organization address address: POLITICKYCH VEZNU 935/13 city: PRAHA postcode: 11000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA)	participant	239˙200.00
3	SZECHENYI ISTVAN UNIVERSITY SZECHENYI ISTVAN UNIVERSITY Organization address address: EGYETEM TER 1 city: GYOR postcode: 9026 website: http://uni.sze.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (GYOR)	participant	193˙200.00
4	BIOFABICS LDA BIOFABICS LDA Organization address address: RUA ALFREDO ALLEN 455/461 city: PORTO postcode: 4200-135 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	participant	133˙400.00
5	TECHNISCHE UNIVERSITAET WIEN TECHNISCHE UNIVERSITAET WIEN Organization address address: KARLSPLATZ 13 city: WIEN postcode: 1040 website: www.tuwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	124˙200.00
6	OSPIN GMBH OSPIN GMBH Organization address address: FEURIGSTRASSE 54 city: BERLIN postcode: 10827 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	105˙800.00
7	USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 14220 website: www.iem.cas.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 4)	participant	105˙800.00
8	UNIVERSITAET GRAZ UNIVERSITAET GRAZ Organization address address: UNIVERSITATSPLATZ 3 city: GRAZ postcode: 8010 website: http://www.uni-graz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	69˙000.00
9	ORTHOSERA GMBH ORTHOSERA GMBH Organization address address: DR. KARL-DORREK-STRASSE 23-29 city: KREMS AN DER DONAU postcode: 3500 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (KREMS AN DER DONAU)	participant	50˙600.00
10	BIONEER A/S BIONEER A/S Organization address address: KOGLE ALLE 2 city: HOERSHOLM postcode: 2970 website: www.bioneer.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HOERSHOLM)	participant	9˙200.00

Map

Project objective

Nanoparticles and new drugs are undergoing complex toxicity evaluation prior to their use in products for customers. However, the traditional pre-clinical testing protocols are delivering significant disadvantages both from ethical (animal testing) and functional (high attrition rate in clinical testing) point of view. ActiTOX reacts to this problem by the development of a novel, pre-clinical, high content, in vitro testing platform focused on the evaluation of nanoparticles/drugs via ADME (absorption, distribution, metabolism, excretion) toxicity studies. In order to advance the current state of art the project will employ biomimetic scaffolds, drug delivery systems, human induced pluripotent stem cells (iPSCs), 3D-microfluidics and modular bioreactor technology. ActiTOX aims to increase the relevance of in vitro studies and provide a scalable approach for their use in drug development and toxicological screening. In order to achieve the project goals, a training network enabling efficient short-term secondments of ER and ESR between academia and industry will be established. The cooperation between stakeholders helps closing the gap between them and oint innovation to foster the current state of the art. ActiTOX will mediate it via networking, research, training, workshop, innovation and dissemination actions in form of short-term secondments. The project fulfils the aim of a RISE project and delivers significant social impact, increases knowledge based economy and creates long lasting cooperation strengthening the European research area.

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The information about "ACTITOX" are provided by the European Opendata Portal: CORDIS opendata.