SRLUNG

"Steroid Receptors in Non-Small Cell Lung Cancer: Diagnostic, prognostic and therapeutic Implications"

Coordinatore	PANEPISTIMIO KRITIS    more  Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 contact info Titolo: Prof. Nome: George Cognome: Tziritas Email: send email Telefono: +30 2810 545210 Fax: +302810 393130
Nazionalità Coordinatore	Greece [EL]
Totale costo	75˙000 €
EC contributo	75˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-03-03   -   2015-03-02

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	PANEPISTIMIO KRITIS  Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 contact info Titolo: Prof. Nome: George Cognome: Tziritas Email: send email Telefono: +30 2810 545210 Fax: +302810 393130	EL (RETHIMNO)	coordinator	75˙000.00

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 Obiettivo del progetto (Objective)

'Lung cancer is currently the most common malignancy and the leading cause of cancer-related death worldwide, varying significantly among geographical areas, sex of patients and distinct populations. Since 1970, incidence, and specific histological characteristics of lung cancer have been significantly modified; however, a disappointing survival rate still persists. A potential steroid relation of lung cancer might be of interest, in view of hormone replacement therapies and contraception strategies followed by a wide part of female population. Hence, the lung remains a favorite site for distant metastases of prostate and breast carcinomas and within this context, a well-established steroid receptor profiling could be crucial in differential diagnosis of primary lung tumors from metastatic foci. Aim of this study is the investigation of the function and the role of sex steroid receptors (both nuclear and extranuclear) in Non-Small Cell Lung Carcinomas (NSCLCs) and their possible prognostic, diagnostic and therapeutic relevance, in association with survival and therapeutic response of patients. Our approach includes three distinct but interrelated objectives: (1) Detection and action of ER and AR in NSCLC cell lines. In this objective, basic research on cells will be initiated. Different ER and AR (intracellular, nuclear and membrane-associated) receptors will be assayed by different methodologies, providing a receptor spectrum of each cell line and providing the more appropriate tools for the detection of the same parameters in human specimens; (2) performing pre-clinical pharmacology studies of SR implication in animal models; (3) validating our findings in clinical specimens and their relation with other established biomarkers, in view of their implementation as potential diagnostic, prognostic or tailored therapeutic targets.'