HERACLES

Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies

Coordinatore	ISTITUTO SUPERIORE DI SANITA    more  Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 contact info Titolo: Dr. Nome: Rosa Cognome: Martoccia Email: send email Telefono: +39 06 4990 2688 Fax: +39 06 4990 3007
Nazionalità Coordinatore	Italy [IT]
Totale costo	3˙784˙916 €
EC contributo	2˙861˙500 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-10-01   -   2017-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ISTITUTO SUPERIORE DI SANITA  Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 contact info Titolo: Dr. Nome: Rosa Cognome: Martoccia Email: send email Telefono: +39 06 4990 2688 Fax: +39 06 4990 3007	IT (ROMA)	coordinator	693˙168.00
2	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Ms. Nome: María ángeles Cognome: López Vázquez Email: send email Telefono: +34 915681462 Fax: +34 915681573	ES (MADRID)	participant	473˙092.00
3	UNIVERSITA DEGLI STUDI DI PAVIA  Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 contact info Titolo: Dr. Nome: Sofia Cognome: Baggini Email: send email Telefono: +39 0382 984227 Fax: +39 0382 986906	IT (PAVIA)	participant	450˙270.00
4	HACETTEPE UNIVERSITESI  Organization address address: HACETTEPE UNIVERSITESI BEYTEPE KAMPUSU REKTORLUK BINASI city: CANKAYA ANKARA postcode: 6800 contact info Titolo: Dr. Nome: Serpil Sevtap Cognome: Benli Email: send email Telefono: +90 312 3052191 Fax: +90 312 3117906	TR (CANKAYA ANKARA)	participant	350˙000.00
5	SPITATUL CLINIC COLENTINA BUCURESTI  Organization address address: SOSEAUA STEFAN CEL MARE 19-21 city: BUCURESTI postcode: 20125 contact info Titolo: Dr. Nome: Maria Cognome: Dinescu Email: send email Telefono: +4021 317 3245 Fax: +40 316 5512	RO (BUCURESTI)	participant	350˙000.00
6	"SPECIALIZED HOSPITAL FOR ACTIVE TREATMENT OF INFECTIOUS AND PARASITIC DISEASES ""PROF. I. KIROV'"  Organization address address: ACAD. IVAN GESHOV BLVD 17 city: SOFIA postcode: 1606 contact info Titolo: Prof. Nome: Kamenna Marinova Cognome: Vutova Email: send email Telefono: 35929523780 Fax: 35929520101	BG (SOFIA)	participant	200˙000.00
7	NAMIK KEMAL UNIVERSITESI*NAMIK KEMAL UNIVERSITY NKU  Organization address address: NAMIK KEMAL UNIVERSITY CAMPUS city: Tekirda? postcode: 59030 contact info Titolo: Mr. Nome: Mustafa Cognome: Durgut Email: send email Telefono: +90 282 250 1511 Fax: +90 282 250 99 08	TR (Tekirda?)	participant	125˙000.00
8	VIRCELL SL  Organization address address: P.I DOS DE OCTUBRE PZA DOMINGUEZ ORTIZ 1 city: SANTA FE GRANADA postcode: 18320 contact info Titolo: Dr. Nome: Arantxa Cognome: Cortés Email: send email Telefono: +34 958 441264 Fax: +34 958 510712	ES (SANTA FE GRANADA)	participant	119˙970.00
9	ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU  Organization address address: VIA FIORENTINA 151 city: SIENA postcode: 53100 contact info Titolo: Dr. Nome: Cristiana Cognome: Tozzi Email: send email Telefono: +39 0577 587906	IT (SIENA)	participant	100˙000.00
10	MINISTRY OF FOOD AGRICULTURE AND LIVESTOCK  Organization address address: Eski?ehir Yolu 9. Km city: Ankara postcode: 6060 contact info Titolo: Dr. Nome: Alparslan Cognome: Temucin Email: send email Telefono: +90 2163901280 Fax: 902164000000	TR (Ankara)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'Human cystic echinococcosis (CE), one of the most widespread helminthic zoonoses, is a chronic disease caused by infection with the larval stage of the tapeworm Echinococcus granulosus. This disease is highly endemic in some southern (Spain and Italy), eastern (Bulgaria and Romania) European countries and associated (Turkey) countries, where it still represents a major health and economic problem. In endemic areas the annual incidence of CE ranges from 1 to 200 per 100,000 inhabitants and 2-3 million cases are globally estimated. Case series and small clinical trials show a mortality rate of 2-4% for CE, but this increases markedly with substandard treatment and care. The diagnosis of human CE is mainly based on imaging techniques and serological confirmation. Clinical decision making is difficult and the natural history of the cyst is still poorly known. CE is chronic, complex and still neglected. For these reasons the main objectives of HERACLES are:

• Identify by ultrasound screening the population affected by CE in endemic rural areas of CEE countries; • Create CEE national registries for surveillance of CE; • Establish a representative bio-bank of genetic Egc isolates and blood/serum/plasma samples; • Validate new molecular-based POC-LOC kits for immunological surveillance, diagnosis and follow-up; • Identify factor/s associated with CE response to therapy or lack thereof through investigation of host-parasite interplay (parasite virulence vs human immunity); • Increase drug bioavailability in an in vivo model, decreasing the length of antiparasitic (ABZ based) treatment of CE and synthesize a new enantiomeric drug based on ABZ.

The project stakeholders, especially the rural populations in which CE is endemic, as well as SMEs, will be engaged as an integral part of the project. Special events to increase general awareness of CE and training activities for local health care providers will be organized.'